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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T60017	5-Bromo-4-chloro-3-indoxyl-beta-D-cellobioside	Others	Others
	5-Bromo-4-chloro-3-indoxyl-beta-D-cellobioside 是用于检测纤维生物水解酶的显色化合物。
T32161	Indoxyl sulfate
	Indoxyl sulfate is a metabolite of tryptophan, showing adverse effects on bones and the central nervous system, having been most frequently implicated as a contributor to renal disease progression and vascular disease
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A12) in the liver. Indoxyl* sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...
T83269	6-Chloro-3-indoxyl-α-D-mannopyranoside
	6-Chloro-3-indoxyl-α-D-mannopyranoside为α-甘露糖苷酶特异性显色底物，酶解反应产生赭色沉淀。
T70312	AZ1366
	AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compared to monotherapy. Activity was limited to CRC explants that displayed irinotecan resistance and increased protein levels of tankyrase and NuMA.
T64292	Simvastatin acid calcium hydrate
	Simvastatin acid (Tenivastatin) calcium hydrate 是一种具有口服具有活力的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin acid calcium hydrate 能够调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。Simvastatin acid calcium hydrate 也能够抑制吲哚酚硫酸盐 (indoxyl sulfate) 介导的活性氧 (ROS) 产生。
T81347	Purple-β-D-Gal
	Purple-β-D-Gal是一种用于检测β-galactosidase活性的底物。该化合物在细胞内被酶解，释放出吲哚基分子。这些分子在原位氧化并二聚成靛蓝，形成不溶于水的色素沉淀，从而实现显色反应。

化合物

5-Bromo-4-chloro-3-indoxyl-beta-D-cellobioside

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

Synonym:

Target:

6-Chloro-3-indoxyl-α-D-mannopyranoside

Simvastatin acid calcium hydrate

Cat. No.	Product Name	Target	Signaling Pathways
T4938	Potassium 1H-indol-3-yl sulfate 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。
T19866	Indican NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside	OAT; MRP	Immunology/Inflammation; Membrane transporter/Ion channel
	Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷，染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中 IS 是尿毒症毒素，是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。
T16885	Simvastatin acid ammonium 辛伐他汀铵盐,Tenivastatin ammonium	Others	Others
	Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 ge