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Cat. No.	Product Name	Target	Signaling Pathways
T1997	JNJ-31020028 JNJ 31020028	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂，对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22，其神经肽 Y2 受体的选择性比人 Y1/Y4/Y5 受体高 100 倍。
T20332L	Bam 12P acetate Bam 12P acetate(75513-71-2 Free base)	Endogenous Metabolite	Metabolism
	Bam 12P acetate 是牛肾上腺、垂体和下丘脑中推定的脑啡肽前体。
TP1104L	Melanin Concentrating Hormone, salmon acetate MCH (salmon),Melanin Concentrating Hormone, salmon acetate(87218-84-6 free base)	Others; Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein; Others
	Melanin Concentrating Hormone, salmon acetate (MCH (salmon))(87218-84-6 free base) 是一种 19 个氨基酸的环状肽，主要在下丘脑中表达。
TP1070L	PACAP (1-27), human, ovine, rat acetate PACAP 1-27 acetate,PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base)	PACAP	GPCR/G Protein
	PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate)(127317-03-7 free base) 是一种新的神经肽，最初从牛下丘脑中分离出来，也存在于人和大鼠中。
T9857L	Vasopressin acetate Vasopressin acetate (11000-17-2 Free base)	Endogenous Metabolite	Metabolism
	Vasopressin acetate 是一种环状九肽，在下丘脑中枢合成。 Vasopressin acetate 作为一种神经递质，通过与特定的 G 蛋白偶联受体结合发挥其作用。
T83651	AC-263093	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	AC-263093 是一种选择性 NPFFR2 激动剂，具有抗焦虑活性，可增加下丘脑室旁核中的c-Fos蛋白表达。
TP1112L	LH-RH, salmon acetate(86073-88-3 free base) Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate	Others	Others
	LH-RH, salmon acetate(86073-88-3 free base) (Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate) 是一种在下丘脑中合成的垂体激素，在控制生殖功能中起着至关重要的作用。
T38193L	β-Endorphin (1-27) (human) acetate β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	β-Endorphin (1-27) (human) acetate 存在于大脑垂体和下丘脑中，具有镇痛活性。 β-Endorphin (1-27) (human) acetate 是一种阿片受体激动剂，对 μ-阿片受体和 δ-阿片受体具有较好的亲和力。
T15368L	Galantide acetate Galantide acetate(138579-66-5 Free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galantide acetate 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂，是一种由甘丙肽和 P 物质片段组成的肽段，在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide acetate 似乎与单一的 SP 受体群结合 (KD~40 nM)。
TP2015L	HS 014 acetate(207678-81-7 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	HS 014 acetate(207678-81-7 free base) 是一种有效的选择性黑皮质素 MC4 受体拮抗剂（克隆的人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM）。体内中枢给药后增加大鼠的食物摄入和小鼠的伤害感受。还抑制室旁下丘脑中 IL-1β 诱导的 Fos 表达。
TP1342	GnRH-I
	GnRH-I is a small 10 amino acid long peptide (decapeptide) from the hypothalamus,It is also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neur
T20403	Dynorphin A (1-8) PH-8P,Dynorphin (1-8)
	Dynorphin (1-8) is an opioid octapeptide from the porcine hypothalamus. It comprises the N-terminal eight residues of dynorphin.
TP1104	Melanin Concentrating Hormone, salmon MCH (salmon)
	Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.
TP1649	Urocortin III, mouse
	Mouse UcnIII is expressed predominantly in regions of the brain known to be involved in stress-related behaviours, and its expression in the hypothalamus increases following restraint.
T37478	Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt)
	Acetyl β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is also present in the human hypothalamus, where it comprises approximately 4.9% of total β-endorphin peptides. Acetyl β-endorphin (1-26) is produced through posttranslational processing of β-endorphin and is processed similarly in rat and human hypothalamus. Levels of acetyl β-endorphin (1-26) increase in the rat pars intermedia and brain stem following chronic administration of haloperidol .
TP1950	PEN(mouse) PEN (mouse)
	Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide. Activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus.
T80116	LHRH	GNRH Receptor	GPCR/G Protein
	LHRH是一种调节生殖功能的下丘脑神经肽，常用于癌症研究。
TP1070	PACAP (1-27), human, ovine, rat PACAP 1-27
	PACAP (1-27) (the N-terminal fragment of PACAP-38) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.
TP1112	Luteinizing Hormone Releasing Hormone (LH-RH), salmon LH-RH, salmon
	Luteinizing Hormone Releasing Hormone (LH-RH) is a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function.
T76301	Agouti-related Protein (AGRP) (83-132) Amide (human)
	Agouti-related Protein (AGRP) (83-132) Amide (human)，一种AGRP的片段，主要在下丘脑弓状核中表达。该化合物主要通过作为黑皮质素-4受体(MC4R)的反向激动剂来增加食物摄入。
T69012	Cinnarizine clofibrate
	Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus
TP1155	Human growth hormone-releasing factor Growth Hormone Releasing Factor human
	Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothalamus. The main role of growth hormo
TP1054	PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA)
	PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP), gastrin releasing peptide (GRP),
T37435	PACAP-related Peptide (rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica...
T76354	LH-RH (4-10)
	LH-RH (4-10)，一种性腺激素释放激素(LHRH)的主要降解产物，属于七肽类，主要在巨噬细胞和II型肺细胞中产生。
TP1102	MCH (salmon) TFA (87218-84-6 free base) Melanin Concentrating Hormone, salmon TFA,MCH (salmon) TFA
	Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. Melanin Concentrating Hormone is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key
TP2215	Agouti-related Protein (AGRP) (25-82), human	Others	Others
	Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesized in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. The appetite-stimulating effect
T28511	Reglitazar JTT-501,JTT501,PNU-182716,PNU182716,PNU-716
	Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non-genetic insulin-resistant models.
T76322	LH-RH II (chicken)
	LH-RH II (chicken) 为家鸡下丘脑黄体生成素释放激素(LHRH)两种形式之一，亦为哺乳动物LHRH的结构变体。该化合物促进家鸡促性腺激素释放。
T76353	LH-RH (7-10)
	LH-RH (7-10)，一种由性腺激素释放激素 (LHRH) 在垂体和下丘脑降解过程中形成的主要四肽降解产物之一，存在于巨噬细胞、I 型样及II 型肺细胞中。
T80145	Galanin-Like Peptide (porcine)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin-Like Peptide (porcine) 是由60个氨基酸组成的神经肽，原始分离自猪下丘脑。这一肽类对GALR2受体表现出高度亲和力（IC50为0.24 nM），而对GALR1受体则表现出较低的亲和性（IC50为4.3 nM）。
T76047	TAK-683 TFA
	TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。
TP2015	HS014 HS 014
	Potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in v
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon...
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T76048	TAK-683 acetate
	TAK-683 acetate是一种高效的KISS1R激动剂(IC50=170 pM)，改善了代谢稳定性。作为九肽metastin的类似物，对人和大鼠的EC50值分别为0.96 nM和1.6 nM。该化合物通过消耗下丘脑GnRH，能够降低血浆FSH、LH、睾酮水平，展示了对研究激素依赖性前列腺癌的潜力。
TP1302	Somatostatin
	Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and
T36521	Alaproclate (hydrochloride)
	Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio...
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF...
T37475	Cyclic ADP-Ribose (ammonium salt) cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt)
	Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with i...

化合物

JNJ-31020028

Cat.No: T1997

Synonym: JNJ 31020028

Target: Neuropeptide Y Receptor

Bam 12P acetate

Cat.No: T20332L

Synonym: Bam 12P acetate(75513-71-2 Free base)

Target: Endogenous Metabolite

Melanin Concentrating Hormone, salmon acetate

Cat.No: TP1104L

Synonym: MCH (salmon),Melanin Concentrating Hormone, salmon acetate(87218-84-6 free base)

Target: Others, Melanin-concentrating Hormone Receptor (MCHR)

PACAP (1-27), human, ovine, rat acetate

Cat.No: TP1070L

Synonym: PACAP 1-27 acetate,PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base)

Target: PACAP

Vasopressin acetate

Cat.No: T9857L

Synonym: Vasopressin acetate (11000-17-2 Free base)

Target: Endogenous Metabolite

AC-263093

Cat.No: T83651

Synonym:

Target: Neuropeptide Y Receptor

LH-RH, salmon acetate(86073-88-3 free base)

Cat.No: TP1112L

Synonym: Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate

Target: Others

β-Endorphin (1-27) (human) acetate

Cat.No: T38193L

Synonym: β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)

Target: Opioid Receptor

Galantide acetate

Cat.No: T15368L

Synonym: Galantide acetate(138579-66-5 Free base)

Target: Neuropeptide Y Receptor

HS 014 acetate(207678-81-7 free base)

Cat.No: TP2015L

Synonym:

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Cat. No.	Product Name	Target	Signaling Pathways
T13433	β-Endorphin, human	Others	Others
	β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus,and is an agonist of opioid receptor.

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