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Cat. No. | Product Name | Target | Signaling Pathways |
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TP1540 |
Jagged-1 (188-204)
Jagged-1 188-204 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Jagged-1 (188-204) 是 JAG-1 蛋白的一个片段。其中 JAG-1 能够诱导单核细胞衍生的人树突状细胞成熟,是一种在培养的和原发性多发性骨髓瘤细胞中高度表达的 Notch 配体。 | |||
T26828 |
BIT225
BIT 225,BIT-225 |
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BIT-225 is a NCp7 zinc finger inhibitor. BIT225 inhibits HIV-1 replication in myeloid dendritic cells. BIT225 inhibits HIV-1 release from human macrophages. BIT225 inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interfer | |||
T78079 |
NF546 hydrate
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P2Y Receptor | GPCR/G Protein; Neuroscience |
NF546 (hydrate)为选择性非核苷酸P2Y11激动剂,具有pEC50值为6.27。该化合物可促进人单核细胞源性树突状细胞释放白细胞介素-8。 | |||
T76023 |
Jagged-1 (188-204) (TFA)
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Jagged-1 (188-204) TFA 是 JAG-1 蛋白的一个片段,具有Notch 激动剂活性。JAG-1 是一种在培养的和原发性多发性骨髓瘤 (MM) 细胞中高度表达的Notch 配体。JAG-1 诱导单核细胞衍生的人树突状细胞成熟。 | |||
T36452 |
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
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1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differe... | |||
T37273 |
BLX3887
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BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro. |1... | |||
T83846 |
HOXB7 (8-25) TFA
Homeobox B7 (8-25) |
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HOXB7 (8-25) 是 homeobox B7 (HOXB7) 的肽段,是细胞增殖的主要调控因子和肿瘤基因途径的激活剂。通过 HOXB7 (8-25) 肽脉冲的树突状细胞展示抗原,这些树突状细胞来源于分离的人类外周血单核细胞(PBMCs),刺激CD4+辅助T细胞的激活和IFN-γ的产生,从而引发特异性和多向性肿瘤反应性的抗肿瘤反应。 | |||
T68182 |
3-Hydroxykynurenamine
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3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ... | |||
T81360 |
PSMα3 TFA
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PSMα3 TFA 作为一种肽类化合物,主要用于诱导生成耐受性的树突细胞(DC),以应用于DC疫苗接种。该化合物能对TLR2和TLR4诱导的DC成熟过程进行调节,抑制促炎和消炎细胞因子的产生,降低抗原摄取,并影响人单核细胞来源DC的渗透和调节能力。此外,PSMα3 TFA 是耐甲氧西林金黄色葡萄球菌(MRSA)中最有毒株释放的关键毒素之一。 | |||
T83847 |
SP-A (196-215) (human) TFA
Surfactant Protein A,SPA4 |
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表面活性蛋白A(SP-A)(196-215)是一种合成肽,与人类SP-A的C末端碳水化合物识别域的196至215氨基酸序列相对应。当浓度为1和10 µM时,它能抑制JAWSII鼠树突细胞中由LPS诱导的TNF-α释放。SP-A(196-215)(75 µM)促使JAWSII细胞吞噬P. aeruginosa。通过气管内给药,SP-A(196-215)(50 µg/动物)降低了小鼠P. aeruginosa感染模型的疾病严重程度和肺部形成菌落数。 | |||
T83852 |
EGFRvIII Peptide TFA
PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide |
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EGFRvIII peptide是一种合成肽,对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头,该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下,它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞(PBMCs)衍生的树突状细胞中,EGFRvIII peptide可诱导抗原呈递,进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5(TLR5)激动剂鞭毛蛋白B共同免疫EGFRvIII peptide(15 µg/动物),在正交GL261胶质母细胞瘤小鼠异种移植模型中,增加了CD8+ T细胞数量,减少了调节性T细胞(Tregs)数量,减少了肿瘤体积,并提高了生存率。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T38394 | PSMα3 | ||
PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus... |