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15

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9989	AChE-IN-27	Others	Others
	AChE-IN-27是一种用于高通量测定的小分子。
T0780	Pyridostigmine bromide 溴吡斯的明,Mestinon,溴化吡啶斯的明	AChE	Neuroscience
	Pyridostigmine bromide (Mestinon) 是一种可逆的胆碱酯酶抑制剂。
T1612	Neostigmine methyl sulfate Normastigmin,甲基硫酸新斯的明,甲硫酸新斯的明,Hodostin,Syntostigmin	AChR; AChE	Neuroscience
	Neostigmine methyl sulfate (Syntostigmin) 是一种乙酰胆碱酯酶的可逆抑制剂, 不能透过血脑屏障。
T8631	pyridostigmine Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum	Others	Others
	Pyridostigmine(Regonol) 是一种乙酰胆碱酯酶抑制剂，可通过增加突触后运动终板的乙酰胆碱来治疗重症肌无力。
T76867	Ravulizumab ALXN1210	Complement System	Immunology/Inflammation
	Ravulizumab (ALXN1210) 是一种靶向补体因子 5 的人源化单克隆抗体，它以高亲和力特异性结合人补体蛋白 C5，可阻断补体激活。Ravulizumab 可用于预防和治疗阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力。
T69472	Edrophonium
	Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
T69158	Ambenonium chloride tetrahydrate
	Ambenonium chloride tetrahydrate is a salt of ambenonium --- a quaternary ammonium compound with parasympathomimetic activity. It is a cholinesterase inhibitor used in the management of myasthenia gravis. Myasthenia gravis occurs when the body produces antibodies against acetylcholine receptors, and thus inhibits signal transmission across the myoneural junction. Ambenonium chloride is a rapid indirect-acting cholinergic agonist that reversibly blocks the activity of acetylcholinesterase, thereb...
T83182	AChRα(97-116)
	AChRα(97-116) 是一种多肽，其应用于诱导实验性自身免疫性重症肌无力（EAMG）。
T69029	Neostigmine
	Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
T69050	Neostigmine hydroxide
	Neostigmine hydroxide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
T7825	Distigmine Bromide BC 51,Ubretid,BC51,Hexamarium,BC-51
	Distigmine Bromide is an acetylcholinesterase inhibitor. It is used for the treatment of underactive neurogenic bladder and myasthenia gravis.
T71758	Ambenonium chloride
	Ambenonium Chloride is the chloride salt form of ambenonium, a quaternary ammonium compound with parasympathomimetic activity. It is a cholinesterase inhibitor used in the management of myasthenia gravis. Myasthenia gravis occurs when the body produces antibodies against acetylcholine receptors, and thus inhibits signal transmission across the myoneural junction. Ambenonium chloride is a rapid indirect-acting cholinergic agonist that reversibly blocks the activity of acetylcholinesterase, thereb...
T33638	Neostigmine Iodide SB 24,SB24,TL1321,TL 1321,TL-1321,SB-24
	Neostigmine Iodide is a parasympathic compound used as a reversible acetylcholinesterase inhibitor to improve muscle tone in patients with myasthenia gravis and in routine anesthesia to reverse the effects of non-depolarizing muscle relaxants such as rocu
T1624	Neostigmine bromide Neoserine bromide,溴化新斯的明,Eustigmin bromide	AChE	Neuroscience
	Neostigmine Bromide 是一种胆碱酯酶抑制剂，不会穿过血脑屏障，可作用于重症肌无力。
T74690	Monarsen
	Monarsen (EN101) 是一种针对人 AChE 基因的反义寡核苷酸。Monarsen 被用于自身免疫性重症肌无力 (MG)的研究，这是一种由针对乙酰胆碱受体 (AChR) 的自身抗体引起的神经肌肉疾病。

化合物

Cat.No: T9989

Target: Others

Pyridostigmine bromide

Cat.No: T0780

Synonym: 溴吡斯的明,Mestinon,溴化吡啶斯的明

Target: AChE

Neostigmine methyl sulfate

Cat.No: T1612

Synonym: Normastigmin,甲基硫酸新斯的明,甲硫酸新斯的明,Hodostin,Syntostigmin

Target: AChR, AChE

Cat.No: T8631

Synonym: Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum

Target: Others

Cat.No: T76867

Synonym: ALXN1210

Target: Complement System

Cat.No: T69472

Ambenonium chloride tetrahydrate

Cat.No: T69158

Cat.No: T83182

Cat.No: T69029

Neostigmine hydroxide

Cat.No: T69050

Distigmine Bromide

Cat.No: T7825

Synonym: BC 51,Ubretid,BC51,Hexamarium,BC-51

Ambenonium chloride

Cat.No: T71758

Neostigmine Iodide

Cat.No: T33638

Synonym: SB 24,SB24,TL1321,TL 1321,TL-1321,SB-24

Neostigmine bromide

Cat.No: T1624

Synonym: Neoserine bromide,溴化新斯的明,Eustigmin bromide

Target: AChE

Cat.No: T74690

Cat. No.	Product Name	Target	Signaling Pathways
T2S1200	Sinapine	Antioxidant; P-gp; AChE	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Sinapine 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T3392	Sinapine thiocyanate	P-gp; AChE	Membrane transporter/Ion channel; Neuroscience
	Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T38606	Sinapine hydroxide
	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4].

天然产物

Cat.No: T2S1200

Target: Antioxidant, P-gp, AChE

Sinapine thiocyanate

Cat.No: T3392

Target: P-gp, AChE

Sinapine hydroxide

Cat.No: T38606

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