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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0328	Hexetidine NSC-17764,海克替啶	Antibacterial; Antifungal	Microbiology/Virology
	Hexetidine (NSC-17764) 是一种口服活性的抗菌抗真菌试剂，可用于口腔感染的相关研究。
T67915	Succinate/succinate receptor antagonist 1	Others	Others
	Succinate/succinate receptor antagonist 1 是一种有效的琥珀酸受体拮抗剂。Succinate/succinate receptor antagonist 1 中断牙龈组织中的琥珀酸信号，抑制琥珀酸受体 1 (SucnRl Antagonist 1) 的激活，对琥珀酸受体 1的 IC50 值为 20 μΜ。Succinate/succinate receptor antagonist 1 可用于治疗牙周病。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T26838	BLXA-4 BLXA4,BLXA-4 ME,BLXA 4,BLXA-4-ME,BLXA4ME
	BLXA-4 is used potentially to treat gingival diseases.
T78549	Ethylene glycol dimethacrylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Ethylene glycol dimethacrylate 是一种具有细胞毒性和基因毒性作用的甲基丙烯酸酯单体。它可增加人牙龈成纤维细胞 (HGF) 内的活性氧 (ROS) 产生，引发 DNA 损伤和细胞凋亡 (apoptosis)，并使细胞周期在 G1/G0 期停滞。
T34811	Terrein NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308
	Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...

化合物

Hexetidine

Cat.No: T0328

Synonym: NSC-17764,海克替啶

Target: Antibacterial, Antifungal

Succinate/succinate receptor antagonist 1

Target: Calcium Channel

BLXA-4

Cat.No: T26838

Synonym: BLXA4,BLXA-4 ME,BLXA 4,BLXA-4-ME,BLXA4ME

Target:

Ethylene glycol dimethacrylate

Cat.No: T78549

Synonym:

Target: Reactive Oxygen Species

Terrein

Cat.No: T34811

Synonym: NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308

Target:

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN2177	Sanggenol L	c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB
	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemother