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Search Results for " fola "

Targets Recommended: Antifolate Others Antifolate

26

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7598	Calcium N5-methyltetrahydrofolate 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328	Others; Antifolate	Cell Cycle/Checkpoint; Others
	Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐，用于治疗心血管疾病、乳腺癌和结肠直肠癌。
T7593	Levomefolate calcium 左旋甲状腺素钙,L-5-甲基四氢叶酸钙	Antifolate	Cell Cycle/Checkpoint
	Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式，是膳食补充剂中生物利用度更高的替代品。
T31224	Piflufolastat DCFPYL	Epigenetic Reader Domain	Chromatin/Epigenetic
	Piflufolastat (DCFPYL) 是一种针对前列腺癌 PSMA 的 PET 显像剂。是一种含氟前列腺特异性膜抗原（PSMA）制剂。Piflufolastat 可用于制备 piflufolastat F 18 (DCFPyL F-18)。
T38492	Folate-PEG2-amine Folate-PEG2-amine
	Folate-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17984	Folate-PEG3-azide	Others	Others
	Folate-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T21476	Niclofolan Niclofolano,Bilevon M,Menichlopholan,ME-3625,Niclofolanum
	Niclofolan, a biphenyl anthelmintic compound, is used orally towards the treatment of Fasciola hepatica infection.
T32705	Levomefolate magnesium L-Methylfolate magnesium
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th
T68232	Epofolate
	Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and s...
T32706	Levomefolate calcium pentahydrate
	Levomefolate calcium pentahydrate is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12. Levomefolate is included in formulations of certain oral contraceptives to ens
T39103	Pafolacianine OTL 38
	Pafolacianine (OTL 38) is a near-infrared dye-based fluorescent marker utilized for identifying ovarian cancer lesions during surgeries.
T7593L	Levomefolate sodium L 5 MTHF sodium,L-5-MTHF sodium,L5MTHF sodium,
	Levomefolate calcium is a primary biologically active form of folate used at the cellular level for dna reproduction, the cysteine cycle and the regulation of homocysteine
T77270	Cholesterol-PEG-Folate (MW 2000)
	Cholesterol-PEG-Folate (MW 2000) 是一种辅料，可用于制备叶酸偶联 PEG 脂质体。
T32176	Iofolastat I 123 MIP 1072,MIP1072,Iofolastat (123-I),(123)I-MIP-1072,MIP-1072
	Iofolastat I 123 is a diagnostic agent under investigation in clinical trial NCT00992745 (A Phase I Pilot Study in Subjects With Metastatic Prostate Cancer).
T26636	Antifolate C2 AGF 154,AGF154,AGF-154	Others	Others
	Antifolate C2 (AGF 154) 具有抗肿瘤活性，在人肿瘤细胞的生长抑制实验中测得IC为0.14nM。Antifolate C2 可用于研究癌症和自身免疫疾病。
T82378	Folate-MS432	PROTACs	PROTAC
	Folate-MS432作为PROTAC，通过叶酸受体依赖途径特异性降解癌细胞中的MEKs。
T34942	Triglutamate folate Pteglu3
	Triglutamate folate is a bioactive chemical.
T17861	DSPE-PEG46-Folate	Others	Others
	DSPE-PEG46-Folate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T26635	Antifolate C1 AGF 94,AGF94,AGF-94
	Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate carrier (RFC).
T40818	Folate-PEG3-amine Folate-PEG3-amine
	Folate-PEG3-amine is a three-unit polyethylene glycol (PEG) linker, which is cleavable. This linker is specifically employed in the synthesis of antibody-drug conjugates (ADCs).
T29460	5-Methyldihydrofolate
	5-Methyldihydrofolate is the primary biologically active form of folate used for DNA reproduction, the cysteine cycle, and the regulation of homocysteine.
T25496	Hexaglutamate folate Pteglu6
	Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube
T20340	10-Formyldihydrofolate
	10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.
T74308	DSPE-PEG-Folate
	DSPE-PEG-Folate (Mw 3350) 是一种含有叶酸的 PEG 衍生物。DSPE-PEG-Folate 具有靶向作用并能与癌细胞中的叶酸受体结合。DSPE-PEG-Folate 形成胶束/脂质双层，可用于靶向给药系统的研究。
T77274	DSPE-PEG-Folate (MW 5000)
	DSPE-PEG-Folate (MW 5000) 是一种含叶酸的 PEG 衍生物，能与癌细胞的叶酸受体结合并具有靶向作用。该化合物可形成胶束/脂质双层，适用于靶向给药系统的研究。
T29461	5-Methyltetrahydrofolate triglutamate 5-Me-Thf(glu)3
	5-Methyltetrahydrofolate triglutamate is a form of folic acid.
T38629	Folate-PEG3-alkyne Folate-PEG3-alkyne
	Folate-PEG3-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

化合物

Calcium N5-methyltetrahydrofolate

Cat.No: T7598

Synonym: 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328

Target: Others, Antifolate

Levomefolate calcium

Cat.No: T7593

Synonym: 左旋甲状腺素钙,L-5-甲基四氢叶酸钙

Target: Antifolate

Cat.No: T31224

Synonym: DCFPYL

Target: Epigenetic Reader Domain

Folate-PEG2-amine

Cat.No: T38492

Synonym: Folate-PEG2-amine

Folate-PEG3-azide

Cat.No: T17984

Target: Others

Cat.No: T21476

Synonym: Niclofolano,Bilevon M,Menichlopholan,ME-3625,Niclofolanum

Levomefolate magnesium

Cat.No: T32705

Synonym: L-Methylfolate magnesium

Cat.No: T68232

Levomefolate calcium pentahydrate

Cat.No: T32706

Cat.No: T39103

Synonym: OTL 38

Levomefolate sodium

Cat.No: T7593L

Synonym: L 5 MTHF sodium,L-5-MTHF sodium,L5MTHF sodium,

Cholesterol-PEG-Folate (MW 2000)

Cat.No: T77270

Iofolastat I 123

Cat.No: T32176

Synonym: MIP 1072,MIP1072,Iofolastat (123-I),(123)I-MIP-1072,MIP-1072

Cat.No: T26636

Synonym: AGF 154,AGF154,AGF-154

Target: Others

Cat.No: T82378

Target: PROTACs

Triglutamate folate

Cat.No: T34942

Synonym: Pteglu3

DSPE-PEG46-Folate

Cat.No: T17861

Target: Others

Cat.No: T26635

Synonym: AGF 94,AGF94,AGF-94

Folate-PEG3-amine

Cat.No: T40818

Synonym: Folate-PEG3-amine

5-Methyldihydrofolate

Cat.No: T29460

Hexaglutamate folate

Cat.No: T25496

Synonym: Pteglu6

10-Formyldihydrofolate

Cat.No: T20340

DSPE-PEG-Folate

Cat.No: T74308

DSPE-PEG-Folate (MW 5000)

Cat.No: T77274

5-Methyltetrahydrofolate triglutamate

Cat.No: T29461

Synonym: 5-Me-Thf(glu)3

Folate-PEG3-alkyne

Cat.No: T38629

Synonym: Folate-PEG3-alkyne

Cat. No.	Product Name	Target	Signaling Pathways
T31836	Folate sodium Folic acid, monosodium salt,Folvite sodium
	Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

天然产物

Folate sodium

Cat.No: T31836

Synonym: Folic acid, monosodium salt,Folvite sodium

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03535	Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) DHFR,Dihydrofolate reductase,folA	Staphylococcus aureus	E. coli
	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.6 kDa and the accession number is P99079.
TMPH-00608	Dihydrofolate reductase Protein, E. coli, Recombinant (His) Dihydrofolate reductase,folA,tmrA	E. coli	E. coli
	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
TMPH-03581	Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) dfrC,folA1,Dihydrofolate reductase,fol...	Staphylococcus epidermidis	E. coli
	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is P0C0P1.
TMPH-01224	Dihydrofolate reductase Protein, Human, Recombinant (His) DHFR,Dihydrofolate reductase	Human	E. coli
	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.

重组蛋白

Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)

Cat.No: TMPH-03535

Species: Staphylococcus aureus

Expression System: E. coli

Dihydrofolate reductase Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00608

Species: E. coli

Expression System: E. coli

Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)

Cat.No: TMPH-03581

Species: Staphylococcus epidermidis

Expression System: E. coli

Dihydrofolate reductase Protein, Human, Recombinant (His)

Cat.No: TMPH-01224

Species: Human

Expression System: E. coli

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