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28

抑制剂 & 化合物

26

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1799	Caspofungin Acetate 醋酸卡泊芬净,L 743873,Cancidas,MK 0991,L 743872	Antibiotic; Antifungal	Microbiology/Virology
	Caspofungin Acetate (MK 0991) 是一种抗真菌药，能够非竞争性地抑制 1,3-β-D 葡聚糖合酶的合成。
T24601	PD 124895 Kazusamycin B,PD124895,PD-124895
	PD 124895 is an antitumor antibiotic isolated from the fermentation broth of Streptomyces sp.
T28307	PD 113270 Antibiotic CL 1565B,CL 1565-B,CL1565-B,PD-113,270,CL-1565-B
	PD 113,270 is an analog of the fermentation products fostriecin with antitumor activity in vitro and in vivo.
T19750	Spinosad Factor D
	Spinosad Factor D is a naturally derived fermentation product. It is used as a pesticide against many different insects.
T28308	PD 113271 Antibiotic CL 1565T,PD113271,CL 1565T,PD-113,271
	PD 113,271 is an analog of the fermentation products fostriecin with antitumor activity in vitro and in vivo.
T37544	Anhydroophiobolin A
	Anhydroophiobolin A is an ophiobolin fungal metabolite that has been found in C. heterostrophus fermentation broths. It is cytotoxic to HepG2 and K562 cancer cells (IC50s = 55.7 and 39.5 μM, respectively).
T26406	A 204 Antibiotic A-204,Antibiotic A204,A-204,Antibiotic A 204,A204
	A 204 is a polycyclic polyether monocarboxylic acid antibiotic isolated from fermentation of strain of Streptomyces albus.
T25642	Lavendamycin NSC-322370,NSC322370,NSC 322370
	Lavendamycin is a naturally occurring chemical isolated from fermentation broth of the soil bacterium Streptomyces lavendulae. It has antibiotic properties and significant anti-proliferative effects against several cancer cell lines.
T37509	Saccharocarcin B
	Saccharocarcin B 是从放线菌 Saccharothrix aerocolongenes subsp.antibiotica SCC1886 的发酵液中分离出来的。
T28962	Thielocin B1 Thielocin-B1
	Thielocin B1 is a protein-protein interaction inhibitor of PAC3 homodimer. Thielocin B1 was isolated as a novel phospholipase A2 inhibitor from the fermentation broth of Thielavia terricola RF-143.
T31184	Dactylocycline E
	Dactylocyclines are novel tetracycline derivatives produced by Dactylosporangium SP. The fermentation of Dactylosporangium sp. (ATCC 53693) produced a mixture of tetracycline derivatives, from which several related tetracycline glycosides, known as rings,
T26499	AB 3217-A AB-3217-A,AB3217-A
	AB 3217-A, an anti-mite substance isolated from the fermentation broth of a streptomycete strain, shows marked activity against the two spotted spider mite, Tetranychus urticae.
T37672	Aspartocin D
	Aspartocin D 可从 Streptomyces canus FIM0916 菌株的发酵液提取中获得。
T74657	Balhimycin
	Balhimycin为一种源自Amycolatopsis sp.发酵产物的糖肽类抗生素，其展现出针对葡萄球菌和厌氧菌的显著抗菌效果。
T68946	Antibiotic MA 144M1
	Antibiotic MA 144M1 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
T68945	Antibiotic MA 144M2
	Antibiotic MA 144M2 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
T38322	A-54556B
	A-54556B is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. hawaiiensis. Like the closely related ADEP, A-54556A , A-54556B is effective against Gram-positive bacteria, including penicillin-resistant S. aureus. A-54556B is also effective against many strains of anaerobic bacteria.
T38321	A-39183A
	A-39183A is an active component of the A-39183 antibiotic complex produced by aerobic fermentation of Streptomyces NRRL 12049. It has activity against penicillin-resistant S. aureus 3055 and S. faecalis X66 (MICs = 32 and 32 μg/ml, respectively) and a variety of Gram-positive and Gram-negative anaerobic bacteria (MICs = 16-128 μg/ml) in an agar dilution assay.
T74037	DL-β-Hydroxybutyryl coenzyme A lithium
	DL-β-Hydroxybutyryl coenzyme A lithium，是丁酸发酵以及赖氨酸和色氨酸代谢过程中的中间体，通过β-羟基丁酸经短链-CoA 合成酶作用生成。
T74171	Crotonyl-CoA
	Crotonyl-CoA，丁酸发酵、赖氨酸和色氨酸代谢中的关键中间体，对脂肪酸和氨基酸的代谢至关重要。
T36613	DL-erythro/threo Sphinganine (d16:0) DL-erythro/threo Sphinganine (d16:0)
	DL-erythro/threo Sphinganine (d16:0) is a sphingolipid that is decreased in rats following long-term, low-dose administration of dimethoate and is used as a biomarker for dimethoate exposure. It has been found in the fermentation broth of Bacterium SRCnm, which has antimicrobial and antioxidant activities. This product is a mixture of sphinganine (d16:0), L-erythro sphinganine (d16:0), D-threo sphinganine (d16:0), and L-threo sphinganine (d16:0).
T26300	Tylosin, lactate lactate (1:1),Tylosin
	Tylosin, lactate is a bacteriostat feed additive used in veterinary medicine. It is a macrolide antibiotic that has a broad spectrum of activity against Gram-positive organisms but a limited range of Gram-negative organisms. It is found naturally as a fer
T35746	Milbemycin A3
	Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A3 is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A3 and milbemycin A4 against adult spider mites, spider mite eggs, and C. elegans are rep...
T81127	Sophorose 2-O-beta-D-Glucopyranosyl-D-glucopyranose
	Sophorose 是一种由酵母产生的微生物糖脂（sophorolipid）的二糖组分，该酵母以槐糖脂（sophorolipids）而著名。作为一种生物表面活性剂，槐糖脂的疏水性使其在多个领域中有着应用价值，例如，它具有抗菌、抗真菌、杀精子、杀病毒和抗癌的功能性特性。此外，在木霉（Trichoderma reesei）发酵过程中，研究已证实Sophorose是促进纤维素酶（cellulase genes）表达的有效诱导剂。
T36367	RK-682 (calcium salt)
	Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the...
T38383	Altemicidin
	Altemicidin is a monoterpene alkaloid originally isolated fromS. sioyaensiswith acaricidal and anticancer activities.1It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s = 0.84 and 0.82 μg/ml, respectively). It is toxic to mice with an LD50value of 0.3 mg/kg. 1.Takahashi, A., Kurasawa, S., Ikeda, D., et al.Altemicidin, a new acari...
T37536	Carbazomycin A
	Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well as the plant pathogenic fungusP. oryzae(MIC = 25 μg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 μg/ml, respectively).2 1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermenta...
T36096	Thiocoraline
	Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA sy...

化合物

Caspofungin Acetate

Cat.No: T1799

Synonym: 醋酸卡泊芬净,L 743873,Cancidas,MK 0991,L 743872

Target: Antibiotic, Antifungal

Cat.No: T24601

Synonym: Kazusamycin B,PD124895,PD-124895

Cat.No: T28307

Synonym: Antibiotic CL 1565B,CL 1565-B,CL1565-B,PD-113,270,CL-1565-B

Spinosad Factor D

Cat.No: T19750

Cat.No: T28308

Synonym: Antibiotic CL 1565T,PD113271,CL 1565T,PD-113,271

Anhydroophiobolin A

Cat.No: T37544

Cat.No: T26406

Synonym: Antibiotic A-204,Antibiotic A204,A-204,Antibiotic A 204,A204

Cat.No: T25642

Synonym: NSC-322370,NSC322370,NSC 322370

Saccharocarcin B

Cat.No: T37509

Cat.No: T28962

Synonym: Thielocin-B1

Dactylocycline E

Cat.No: T31184

Cat.No: T26499

Synonym: AB-3217-A,AB3217-A

Cat.No: T37672

Cat.No: T74657

Antibiotic MA 144M1

Cat.No: T68946

Antibiotic MA 144M2

Cat.No: T68945

Cat.No: T38322

Cat.No: T38321

DL-β-Hydroxybutyryl coenzyme A lithium

Cat.No: T74037

Cat.No: T74171

DL-erythro/threo Sphinganine (d16:0)

Cat.No: T36613

Synonym: DL-erythro/threo Sphinganine (d16:0)

Tylosin, lactate

Cat.No: T26300

Synonym: lactate (1:1),Tylosin

Cat.No: T35746

Cat.No: T81127

Synonym: 2-O-beta-D-Glucopyranosyl-D-glucopyranose

RK-682 (calcium salt)

Cat.No: T36367

Cat.No: T38383

Cat.No: T37536

Cat.No: T36096

Cat. No.	Product Name	Target	Signaling Pathways
T9076	Spinosad	Others	Others
	Spinosad 是在土壤细菌 S. spinosa 中发现的一种杀虫剂，是大环内酯多杀菌素 A 和多杀菌素 D 的混合物，可作为昆虫烟碱乙酰胆碱酯酶受体 (nAChRs) 的激动剂。它具有优良的环境和哺乳动物毒理学特征，以及杀灭幼虫的活性。
T4S0554	Theaflavine-3,3'-digallate TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素	Others	Others
	Theaflavine-3,3'-digallate (theaflavin digallate) 和乳酸一起可以减少单纯疱疹病毒的传播。
T2719	Succinic acid Asuccin,Amber acid,琥珀酸,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid	Endogenous Metabolite	Metabolism
	Succinic acid (1,2-Ethanedicarboxylic acid) 是无氧代谢的发酵产物，也是三羧酸循环的中间产物。
T2O2666	Methyl stearate Stearic Acid methyl ester,硬脂酸甲酯,Methyl Octadecanoate	Others	Others
	Methyl stearate (Methyl Octadecanoate) 是大豆和油菜籽生物柴油的组分，分离自 Rheum palmatumL 中。
T10943	D-(-)-Lactic acid (R)-2-Hydroxypropionic acid,D-乳酸	Others; Endogenous Metabolite	Metabolism; Others
	D-(-)-Lactic acid 是糖发酵（氧化、代谢）中的一种正常中间体。它被鉴定为植物中 ProDH（脯氨酸脱氢酶）的竞争性抑制剂。
T40585	1,3-Propanediol	Others	Others
	1,3-Propanediol 是微生物经甘油发酵产生的化合物。
T7926	Carmoisine Azo Rubine,Chromotrope FB,偶氮玉红,铬变素FB	Others	Others
	Carmoisine (Azo Rubine) 是一种可用作食品添加剂的偶氮染料。
T31708	Ethyl caprate Decanoic acid, ethyl ester,Ethyl decylate,Ethyl decanoate,Ethyl caprinate,Capric acid ethyl ester
	Ethyl caprate, also known as Ethyl decanoate, is a fatty acid ester formed from capric acid and ethanol. This ester is a frequent product of fermentation during winemaking, especially at temperatures above 15 °C.
T1160	Fusidic acid Fusidine,夫西地酸	Others; CAT; Antibacterial; Antibiotic	Microbiology/Virology; Others; oxidation-reduction
	Fusidic acid (Fusidine) 是一种从 Fusidium coccineum 发酵液中分离出来的甾体类抗生素。它通过阻止核糖体释放翻译延长因子 G 来抑制细菌的生长。
TJS2216	Aurantiamide acetate 金色酰胺醇酯,Asperglaucide	Cysteine Protease	Proteases/Proteasome
	Aurantiamide acetate (Asperglaucide) 是抑制口服有活性的 cathepsin 选择性抑制剂，分离自 Portulaca oleracea L。它具有抗炎作用，可用于研究炎性相关疾病。
T13305	Viridicatol	Anti-infection; Antifungal	Microbiology/Virology
	Viridicatol 是从夹竹桃的内生真菌青霉菌属的发酵中分离出的一种喹诺酮类生物碱，对金黄色葡萄球菌有抗菌活性，MIC 值为 15.6 μg/mL。
T4876	2-(1H-Indol-3-yl)ethan-1-ol Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇	Others; Endogenous Metabolite	Metabolism; Others
	2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) 是在双硫仑治疗后在肝脏中形成的代谢物，可诱导人类睡眠。它也是酒精发酵的二次产物。
T37341	N-Acetyltyramine	Antibacterial	Microbiology/Virology
	N-Acetyltyramine 是一种群体感应抑制剂，由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。
T4751	(2R,3R)-Butane-2,3-diol (2R,3R)-(-)-2,3-Butanediol,levo-2,3-Butanediol,(2R,3R)-(-)-2,3-丁二醇	Others; Endogenous Metabolite	Metabolism; Others
	(2R,3R)-Butane-2,3-diol (levo-2,3-Butanediol) 是内源性代谢产物的一种。
T67302	2,3-Pentanedione Acetylpropionyl	Others	Others
	2,3-Pentanedione 是一种食品添加剂，也作为发酵产物自然存在于啤酒、葡萄酒和酸奶中，并在咖啡豆烘焙过程中释放。吸入2,3-Pentanedione 被认为是人严重呼吸道疾病（包括闭塞性细支气管炎）的原因。
T41122	1,3-Dihydroxyacetone	Endogenous Metabolite	Metabolism
	1,3-Dihydroxyacetone 是防晒美黑护肤制剂的主要活性成分，是合成各种精细化学品的重要前体，也是一种食品添加剂，可通过在 Gluconobacter oxydans 上进行微生物发酵实现工业规模生产。1,3-Dihydroxyacetone 具有提高cAMP 水平的能力。
T6717	Vanillin Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107	Others; Endogenous Metabolite	Metabolism; Others
	Vanillin (Zimco) 是一种天然产物，是从香草豆中提取的单个分子，是香水，食品和药物中广泛使用的气味。
T33641	Neoxaline Nedoxaline
	Neoxaline is an alkaloid isolated from fermentation broth of Aspergillus japonicus.
TN6447	Cyclo(Leu-Val)
	Cyclo(Leu-Val) is a cyclic dipeptide from the fermentation broth of F8712 strain.
T40134	Diacetyl Agrochelin
	Diacetyl Agrochelin, an acetyl derivative of Agrochelin, is a compound synthesized through the fermentation of marine Agrobacterium sp. It possesses cytotoxic properties against tumor cell lines.
T40133	Agrochelin
	Agrochelin, an alkaloid cytotoxic antibiotic, is synthesized via fermentation of a marine Agrobacterium sp. This compound demonstrates cytotoxic activity against tumor cell lines.
T73888	Berninamycin D
	Berninamycin D 是一种环状肽真菌代谢物，从 Streptomyces bernensis 中分离出来。
T40383	Monensin B
	Monensin B is a polyketide compound derived from the bacterium Streptomyces cinnamonensis. Its production involves the fermentation of Streptomyces cinnamonensis, resulting in a mixture of Monensin A and Monensin B. The ratio of these two compounds depends on the concentrations of ethylmalonyl-CoA and methylmalonyl-CoA.
T71750	Quinolactacin A1
	Quinolactacin A1 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，可从Penicillium citrinum 中得到。Quinolactacin A1 可用于阿尔茨海默病的研究。
T82750	Cellooctaose
	Cellooctaose，由8个葡萄糖残基构成的低聚糖，作为低成本的多糖，在发酵中能促进重组乳酸菌的生长。
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....

天然产物

Cat.No: T9076

Target: Others

Theaflavine-3,3'-digallate

Cat.No: T4S0554

Synonym: TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素

Target: Others

Cat.No: T2719

Synonym: Asuccin,Amber acid,琥珀酸,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid

Target: Endogenous Metabolite

Methyl stearate

Cat.No: T2O2666

Synonym: Stearic Acid methyl ester,硬脂酸甲酯,Methyl Octadecanoate

Target: Others

D-(-)-Lactic acid

Cat.No: T10943

Synonym: (R)-2-Hydroxypropionic acid,D-乳酸

Target: Others, Endogenous Metabolite

1,3-Propanediol

Cat.No: T40585

Target: Others

Cat.No: T7926

Synonym: Azo Rubine,Chromotrope FB,偶氮玉红,铬变素FB

Target: Others

Cat.No: T31708

Synonym: Decanoic acid, ethyl ester,Ethyl decylate,Ethyl decanoate,Ethyl caprinate,Capric acid ethyl ester

Cat.No: T1160

Synonym: Fusidine,夫西地酸

Target: Others, CAT, Antibacterial, Antibiotic

Aurantiamide acetate

Cat.No: TJS2216

Synonym: 金色酰胺醇酯,Asperglaucide

Target: Cysteine Protease

Cat.No: T13305

Target: Anti-infection, Antifungal

2-(1H-Indol-3-yl)ethan-1-ol

Cat.No: T4876

Synonym: Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇

Target: Others, Endogenous Metabolite

N-Acetyltyramine

Cat.No: T37341

Target: Antibacterial

(2R,3R)-Butane-2,3-diol

Cat.No: T4751

Synonym: (2R,3R)-(-)-2,3-Butanediol,levo-2,3-Butanediol,(2R,3R)-(-)-2,3-丁二醇

Target: Others, Endogenous Metabolite

2,3-Pentanedione

Cat.No: T67302

Synonym: Acetylpropionyl

Target: Others

1,3-Dihydroxyacetone

Cat.No: T41122

Target: Endogenous Metabolite

Cat.No: T6717

Synonym: Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107

Target: Others, Endogenous Metabolite

Cat.No: T33641

Synonym: Nedoxaline

Cat.No: TN6447

Diacetyl Agrochelin

Cat.No: T40134

Cat.No: T40133

Cat.No: T73888

Cat.No: T40383

Quinolactacin A1

Cat.No: T71750

Cat.No: T82750

Cat.No: T38069

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