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25

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T76581	HHV-2 Envelope Glycoprotein G (552-574)
	HHV-2 包膜糖蛋白 G (552-574) 是 gG-2 的免疫显性区域，能够与所有单纯疱疹 (HSV-2) 血清产生反应。
T80120	FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578)	HSV	Microbiology/Virology
	FITC-εAhx-HHV-2 EnvelopeGlycoproteinG (561-578) 是带有FITC标记的糖蛋白G (gG-2)的免疫原性片段，涵盖了其氨基酸序列的561至578位点。此段具有广泛的与单纯疱疹病毒2型(HSV-2)血清呈现交叉反应的特性。
T16276	NBD-556	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	NBD-556是一种 CD4 模拟物，识别 HIV-1 包膜蛋白 gp120 并诱导 gp120 重组，类似于 CD4 结合，可阻断 gp120-CD4 的相互作用。
T26392	5M038
	5M038, a novel inhibitor of HIV envelope-mediated fusion, strongly inhibits gp41-mediated membrane fusion.
T30532	BMS-585248 CHEMBL236995,CIO2TZZ9H1,BMS 585248,UNII-CIO2TZZ9H1
	BMS-585248 is a highly effective HIV-1 adhesion inhibitor that targets the viral envelope protein gp120.
TP2401	Peptide T amide D-Ala(1)-peptide T amide
	Peptide T amide is an octapeptide segment of HIV envelope gp120 and is used in AIDS therapy.
T68898	Dequalinium Bromide
	Dequalinium Bromide is a HIV-1 fusion inhibitor, targeting the membrane-proximal external region of Env spikes, specifically inhibiting the HIV-1 envelope-mediated membrane fusion by blocking CD4-induced conformational changes.
T82711	CKS-17
	CKS-17为一合成逆转录病毒包膜肽，其氨基酸序列高度保守，在多种动物及人类逆转录病毒跨膜包膜蛋白中均可见。作为免疫调节表位，CKS-17展现出对众多免疫功能的抑制作用。
T17026L	Tecovirimat hydrate ST246,ST 246,ST-246,SIGA 246,SIGA246,SIGA-246
	Tecovirimat,(ST-246, SIgA-246) is an inhibitor of p37 envelope proteins used to treat smallpox infection. Tecovirimat is an antiviral drug that is active against orthopoxviruses such as smallpox and is currently undergoing clinical trials. Its role is to
T62709	EBOV-GP-IN-1
	EBOV-GP-IN-1 (Compound 28) 是一种有效的 Ebola 进入抑制剂，能够作用于埃博拉病毒包膜糖蛋白（EBOV-GP）(IC50: 0.05 μM)。
T80970	Tobevibart	HBV	Microbiology/Virology
	Tobevibart为IgG1-lambda亚型，针对HBV（乙型肝炎病毒）表面包膜蛋白的人源化单克隆抗体，具有抗病毒活性。
T80580	Zinlirvimab 10-1074
	Zinlirvimab是一种IgG1-λ2类人源化HIV中和抗体，专一性靶向HIV-1 gp120包膜糖蛋白(IIIB gp120 V3环)。
T76530	HBV Seq2 aa:208-216
	HBVSeq2 aa:208-216，作为HBsAg衍生的CD8表位肽，是乙型肝炎病毒大包膜蛋白一部分，目前正被研究。
T37461	EOS (d18:1/32:1/18:2)
	EOS is a ceramide found in the outer layer of the epidermis in mammals. It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the ver...
T83707	F9170 TFA
	F9170是一种抗病毒肽，对应HIV-1包膜糖蛋白的789-803氨基酸。它与HIV-1包膜蛋白胞浆尾部的LLP1域结合，并抑制HIV-1 IIIB对MT-2细胞的感染(EC50 = 0.19 µM)。在恒河猴模型的类人猿免疫缺陷病毒(SHIV)感染中，F9170 (3 mg/kg)能降低血浆病毒负荷。
T76514	HCV-1 e2 Protein (554-569)
	HCV-1 e2 Protein (554-569) 是一段重要的丙型肝炎病毒(HCV) e2 蛋白的抗原区域，具有一个推定的 N-糖基化位点，这个位点被认为之前影响了e2蛋白的免疫识别。
TP2184	matrix protein (3-15) [Zaire ebolavirus]	Others	Others
	matrix protein (3-15) [Zaire ebolavirus] is a peptide of the structural proteins linking the viral envelope with the zaire ebolavirus core. Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of
T23407	surface antigen (208-215) [Hepatitis B Virus]	Others	Others
	The nucleocapsid of the hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to
T77010	Fiztasovimab
	Fiztasovimab (NPC-21; EV2038) 是一种全人 IgG1λ 单克隆抗体，具有抗人巨细胞病毒 (hCMV) 活性。Fiztasovimab 通过结合 hCMV 包膜上糖蛋白 B 的抗原结构域 1 发挥中和活性。Fiztasovimab 还抑制 hCMV 的细胞间传播。
T80089	HCV-1 e2 Protein (554-569) (TFA)
	HCV-1 e2 Protein (554-569) TFA 为丙型肝炎病毒（HCV）e2 蛋白关键抗原区段，含一个假定 N-糖基化位点，该位点早先推测会影响 e2 蛋白的免疫识别。
T76516	HCV-1 e2 Protein (484-499)
	HCV-1 e2 蛋白 (484-499) 是由 16 个氨基酸组成的肽。 HCV-1 e2 蛋白 (484-499) 来源于具有 HCV 抗体的个体血清中丙型肝炎病毒的包膜 2 蛋白。
T76292	Tifuvirtide
	Tifuvirtide (T-1249) 是一种肽类人类免疫缺陷病毒 1 型(HIV-1)融合抑制剂。Tifuvirtide 是一种合成设计的杂合逆转录病毒包膜多肽。Tifuvirtide 具有抗逆转录病毒活性。Tifuvirtide 可用于HIV 感染的研究。
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T75444	Peniterphenyl A
	Peniterphenyl A，一种源于深海青霉属植物的天然产物，能够抑制HSV-1/2病毒的细胞内入侵。它可能通过与HSV-1/2病毒的糖蛋白D直接相互作用，干扰病毒的吸附和膜融合过程，进而有效阻断病毒感染。因此，Peniterphenyl A是抗HSV-1/2研究领域中一个极具潜力的先导化合物。
TP2182	Lamin fragment	Others	Others
	Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin

化合物

HHV-2 Envelope Glycoprotein G (552-574)

Cat.No: T76581

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578)

Cat.No: T80120

Target: HSV

Cat.No: T16276

Target: HIV Protease

Cat.No: T26392

Cat.No: T30532

Synonym: CHEMBL236995,CIO2TZZ9H1,BMS 585248,UNII-CIO2TZZ9H1

Peptide T amide

Cat.No: TP2401

Synonym: D-Ala(1)-peptide T amide

Dequalinium Bromide

Cat.No: T68898

Cat.No: T82711

Tecovirimat hydrate

Cat.No: T17026L

Synonym: ST246,ST 246,ST-246,SIGA 246,SIGA246,SIGA-246

Cat.No: T62709

Cat.No: T80970

Target: HBV

Cat.No: T80580

Synonym: 10-1074

HBV Seq2 aa:208-216

Cat.No: T76530

EOS (d18:1/32:1/18:2)

Cat.No: T37461

Cat.No: T83707

HCV-1 e2 Protein (554-569)

Cat.No: T76514

matrix protein (3-15) [Zaire ebolavirus]

Cat.No: TP2184

Target: Others

surface antigen (208-215) [Hepatitis B Virus]

Cat.No: T23407

Target: Others

Cat.No: T77010

HCV-1 e2 Protein (554-569) (TFA)

Cat.No: T80089

HCV-1 e2 Protein (484-499)

Cat.No: T76516

Cat.No: T76292

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

Peniterphenyl A

Cat.No: T75444

Cat.No: TP2182

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T19719	TBMP butylated hydroxyanisole	Others	Others
	TBMP (butylated hydroxyanisole) 是病毒包膜蛋白血凝素 (HA) 介导的进入新型抑制剂。
T0884	1-Docosanol Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol	Antifection; HSV	Microbiology/Virology
	1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇，局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
T80003	Wulfenioidin H
	Wulfenioidin H (Compound 5) 是二萜类化合物，对抗寨卡病毒(ZIKV)活性显著，其EC50为 8.50 μM。该化合物能够通过抑制ZIKV包膜(E)蛋白表达来干预病毒复制。
T80002	Wulfenioidin F	Virus Protease	Microbiology/Virology
	Wulfenioidin F是从Orthosiphon wulfenioides全草分离的二萜类化合物。该化合物对抗寨卡病毒(ZIKV)活性显著，其半数有效浓度(EC50)为8.07 μM。Wulfenioidin F的抗病毒机制通过抑制ZIKV包膜(E)蛋白的表达，从而干扰病毒复制。

天然产物

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Cat.No: T19719

Synonym: butylated hydroxyanisole

Target: Others

Cat.No: T0884

Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Target: Antifection, HSV

Cat.No: T80003

Cat.No: T80002

Target: Virus Protease

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