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12

抑制剂 & 化合物

6

天然产物

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Cat. No. Product Name Target Signaling Pathways
T20958 Hexazinone

Others Others
Hexazinone 是三嗪家族的广谱除草剂。 Hexazinone 通过与光系统 II 中电子传递链的 D-1 醌蛋白结合来抑制光合作用。
T5117 Hexaflumuron

Others Others
Hexazinone 是一种三嗪家族的非选择性除草剂。它能够同光系统 II 电子传递链的 D-1 醌蛋白结合,抑制光合作用的发生。
T40515 Metamitron

Metamitron 是一种光合电子传递链抑制剂,可用作化学稀释剂。
T0412 Idebenone

艾地苯醌,CV-2619

Apoptosis; Antioxidant; Mitochondrial Metabolism Apoptosis; Metabolism; oxidation-reduction
Idebenone (CV-2619) 是一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障,诱导细胞凋亡。
T5337 IACS-010759

IACS-10759,IACS 10759,IACS10759

Apoptosis; Others; Mitochondrial Metabolism Apoptosis; Metabolism; Others
IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡,有研究复发/难治性 AML 和实体瘤潜力。
T12049 MitoTam bromide, hydrobromide

MitoTam bromide hydrobromide

Others Others
MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.
T27444 GSK 932121

GSK-932121,GSK932121

GSK 932121 is a potent antimalarial agent. GSK 932121 inhibits selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III).
T34084 Plastoquinone

Q 254,Q-254,Q254

Plastoquinone is a polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical
T36203 Menaquinone 9

MK-9,Vitamin K2(45),Menaquinone 9

Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.
T37519 Diquat (bromide)

Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Form...
T36114 Coenzyme Q2

Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. For...
T37498 Antimycin A4

Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial elect...

化合物

Hexazinone
Cat.No: T20958
Synonym:
Target: Others
Hexaflumuron
Cat.No: T5117
Synonym:
Target: Others
Metamitron
Cat.No: T40515
Synonym:
Target:
Idebenone
Cat.No: T0412
Synonym: 艾地苯醌,CV-2619
Target: Apoptosis, Antioxidant, Mitochondrial Metabolism
IACS-010759
Cat.No: T5337
Synonym: IACS-10759,IACS 10759,IACS10759
Target: Apoptosis, Others, Mitochondrial Metabolism
MitoTam bromide, hydrobromide
Cat.No: T12049
Synonym: MitoTam bromide hydrobromide
Target: Others
GSK 932121
Cat.No: T27444
Synonym: GSK-932121,GSK932121
Target:
Plastoquinone
Cat.No: T34084
Synonym: Q 254,Q-254,Q254
Target:
Menaquinone 9
Cat.No: T36203
Synonym: MK-9,Vitamin K2(45),Menaquinone 9
Target:
Diquat (bromide)
Cat.No: T37519
Synonym:
Target:
Coenzyme Q2
Cat.No: T36114
Synonym:
Target:
Antimycin A4
Cat.No: T37498
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T8433 HQNO

Mitochondrial Metabolism Metabolism
HQNO 是一种电子传递链抑制剂,对 complex III 的Kd 值为 64 nM,由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
T5573 Coenzyme Q9

辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9

Apoptosis; Endogenous Metabolite Apoptosis; Metabolism
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。
T5300 Ammonium formate

甲酸铵,Formic acid ammonium salt

Others Others
Ammonium formate (Formic acid ammonium salt) 是最简单的羧酸。它通过抑制细胞色素氧化酶活性(电子传递链的末端电子受体)来负责代谢性酸中毒和破坏线粒体电子传递和能量产生。
T21494 Oligomycin

HIF Angiogenesis; Chromatin/Epigenetic
Oligomycin 是一种抗真菌抗生素,是 H+-ATP 合成酶的抑制剂。Oligomycin 能够阻断氧化磷酸化和电子传递链。Oligomycin 对缺氧性肿瘤细胞 HIF-1alpha 表达具有抑制作用。
T5291 Malonic acid

Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid

Others Others
Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子:它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关,这是一种先天性代谢错误。
TN4418 Lasiodiplodin

ATPase; TNF Apoptosis; Membrane transporter/Ion channel
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain.

天然产物

HQNO
Cat.No: T8433
Synonym:
Target: Mitochondrial Metabolism
Coenzyme Q9
Cat.No: T5573
Synonym: 辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9
Target: Apoptosis, Endogenous Metabolite
Ammonium formate
Cat.No: T5300
Synonym: 甲酸铵,Formic acid ammonium salt
Target: Others
Oligomycin
Cat.No: T21494
Synonym:
Target: HIF
Malonic acid
Cat.No: T5291
Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid
Target: Others
Lasiodiplodin
Cat.No: TN4418
Synonym:
Target: ATPase, TNF
TargetMol Loading
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