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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TD0092	Naphthoresorcinol 间萘二酚,1,3-二羟基萘,1,3-Dihydroxynaphthalene	Others	Others
	Naphthoresorcinol (1,3-Dihydroxynaphthalene) 是一种荧光染料 (λex=330 nm, λem=380 nm)，与 NPPD (一种示踪剂) 和浓 HCl 反应显示出红色。它也能够作为测定碳水化合物的背景电解质 (BGE) 。
T65281	Magnesium acetate tetrahydrate	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	Magnesium acetate tetrahydrate 是无水醋酸镁盐的水合形式。Magnesium acetate tetrahydrate 常用来合成其他化合物，可作为电解质补充剂或分子生物学实验中的试剂。
T0114	Trichlormethiazide Naqua,Metahydrin,三氯噻嗪,Trichlormetazid	ATPase; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Trichlormethiazide (Naqua) 是一种口服具有活力的噻嗪类利尿剂，具有降压作用。它能够提高急性肾功能衰竭大鼠的尿量、Na 和 K 排泄，并有改善降低的肌酐清除率。
T37708	17(R)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM.
T35849	17(S)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM.
TP2034	Guanylin(human) Guanylin (human)
	Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.
T35847	16(R)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that...
T37960	Guanylin(human) TFA
	Guanylin (human) TFA is a 15-amino acid peptide that serves as an endogenous activator of intestinal guanylate cyclase. This compound is primarily located in the gastrointestinal tract, where it regulates electrolyte and water transport in the intestinal and renal epithelia through a mechanism dependent on cyclic GMP. [1][2]
T22575	Angiotensin Fragment 1-7 (acetate)	Others	Others
	Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis
T35523	(±)17-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.
T35848	16(S)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM.
T80438	Atrial natriuretic peptide (3-28) (human) ANP (3-28) (human)	Endothelin Receptor	GPCR/G Protein
	Atrial natriuretic peptide (3-28) (human) 是由心房心肌细胞合成并分泌的肽类激素，主要在调节血压、体液平衡及电解质稳态方面发挥作用。
T35465	(±)16-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits pro...
T83905	Brain Natriuretic Peptide-32 (rat) acetate BNP (14-45),B-type Natriuretic Peptide-32,Brain Natriuretic Polypeptide-32,BNP-32
	BNP-32（Brain natriuretic peptide-32）是心血管激素前体proBNP的肽段，能够结合大鼠血管平滑肌上的利钠肽受体（IC50 = 7.3 nM），并在同样的细胞中促进cGMP积累（EC50 = 170 nM）。BNP-32还能使经去甲肾上腺素预收缩的孤立大鼠主动脉条带松弛（EC50 = 6.7 nM），当以3 µg/kg的剂量给药时，能增加大鼠的尿量和尿液电解质排泄，并诱导低血压。
T36660	Olsalazine-13C6 Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...

化合物

Naphthoresorcinol

Cat.No: TD0092

Synonym: 间萘二酚,1,3-二羟基萘,1,3-Dihydroxynaphthalene

Target: Others

Magnesium acetate tetrahydrate

Cat.No: T65281

Target: Endogenous Metabolite, Antibacterial

Trichlormethiazide

Cat.No: T0114

Synonym: Naqua,Metahydrin,三氯噻嗪,Trichlormetazid

Target: ATPase, Carbonic Anhydrase

Cat.No: T37708

Cat.No: T35849

Guanylin(human)

Cat.No: TP2034

Synonym: Guanylin (human)

Cat.No: T35847

Guanylin(human) TFA

Cat.No: T37960

Angiotensin Fragment 1-7 (acetate)

Cat.No: T22575

Target: Others

Cat.No: T35523

Cat.No: T35848

Atrial natriuretic peptide (3-28) (human)

Cat.No: T80438

Synonym: ANP (3-28) (human)

Target: Endothelin Receptor

Cat.No: T35465

Brain Natriuretic Peptide-32 (rat) acetate

Cat.No: T83905

Synonym: BNP (14-45),B-type Natriuretic Peptide-32,Brain Natriuretic Polypeptide-32,BNP-32

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Cat. No.	Product Name	Target	Signaling Pathways
T19614	18-Hydroxycorticosterone	Others	Others
	18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.

天然产物

18-Hydroxycorticosterone

Cat.No: T19614

Target: Others

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