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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4274	Melitracen hydrochloride 盐酸美利曲辛,盐酸美力他欣,Thymeol hydrochloride,Melixeran	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Melitracen hydrochloride (Thymeol hydrochloride) 是一种可口服的双相抗抑郁药和抗焦虑药。它可以通过突触前膜抑制去甲肾上腺素和5-羟色胺(5-HT)的吸收，从而诱导突触空间中单胺递质的增加。
T23283	2-Methoxyidazoxan monohydrochloride RX 821002 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) 是高效的 alpha 2r 肾上腺素受体选择性拮抗剂，对 imidazoline 拮抗作用很小或没有。它对 (豚鼠) alpha 2D 肾上腺素受体 (pKd9.7) 的亲和力明显高于 (兔子) alpha 2A 肾上腺素受体 (pKd8.2)。
T23479L	TT-232 TFA（147159-51-1 free base）	Others	Others
	TT-232 TFA（147159-51-1 free base）诱导人结肠肿瘤细胞系 SW620 中磷酸酪氨酸磷酸酶活性的双相激活。
T68765	Spirorenone
	Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination)....
T37297	Ru360
	Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce...

化合物

Melitracen hydrochloride

Cat.No: T4274

Synonym: 盐酸美利曲辛,盐酸美力他欣,Thymeol hydrochloride,Melixeran

Target: Dopamine Receptor, 5-HT Receptor

2-Methoxyidazoxan monohydrochloride

Cat.No: T23283

Synonym: RX 821002 hydrochloride

Target: Adrenergic Receptor

TT-232 TFA（147159-51-1 free base）

Cat. No.	Product Name	Target	Signaling Pathways
T7033	Rosmanol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。
TN3973	Epinodosin	Others	Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.