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Search Results for " antifertility "

13

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7943	Fluphenazine decanoate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。
T24415	Lotrifen Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta	Others	Others
	Lotrifen (Privaprol) 是一种非激素抗生育药物，Lotrifen 引起妊娠停止和复旧。在胚泡着床后，它直接作用于受精卵，受精卵经历一个缓慢而逐渐的退化过程，并以受精卵的再吸收或排出而结束。
T24187	J 628 J-628,J628
	J 628 is a synthetic "impeded" estrogen derivative. It also has some postcoital antifertility activity.
T24275	L 10503 L10503,NSC-298267,NSC298267,L-10503,NSC 298267
	L 10503 is an antifertility agent.
T20272	Diethyl adipate AI300342,AI3-00342 AI3 00342,NSC19160,NSC 19160,NSC-19160
	Diethyl adipate has an effect of antifertility.
T24276	L 11204 DL 204IT,L-11204,DL 204 IT,DL 204,L11204
	L 11204 is an antifertility in vivo. It is an inhibitor of prostaglandin synthesis.
T28609	Rohitukine NSC623611,NSC-623611,NSC 623611
	Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and antileishmanial compound.
T9586	Broparestrol (E)-	Others	Others
	Broparestrol (E)- 具有抗生育活性，是啮齿动物乳腺肿瘤发生的有效抑制剂。
T36621	Prostaglandin F2β
	Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.
T36153	15(S)-15-methyl Prostaglandin D2 15(S)-15-methyl Prostaglandin D2
	15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).
T37326	Prostaglandin F2α 1,11-lactone Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) 是前列腺素 F2α 的脂溶性前药，可用于治疗青光眼的研究。 Prostaglandin F2α 1,11-lactone 作为抗生育剂具有活性，可大大降低血管活性。
T71133	Azacosterol hydrochloride
	Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone pr...
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...

化合物

Fluphenazine decanoate

Cat.No: T7943

Target: Dopamine Receptor

Cat.No: T24415

Synonym: Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta

Target: Others

Cat.No: T24187

Synonym: J-628,J628

Cat.No: T24275

Synonym: L10503,NSC-298267,NSC298267,L-10503,NSC 298267

Diethyl adipate

Cat.No: T20272

Synonym: AI300342,AI3-00342 AI3 00342,NSC19160,NSC 19160,NSC-19160

Cat.No: T24276

Synonym: DL 204IT,L-11204,DL 204 IT,DL 204,L11204

Cat.No: T28609

Synonym: NSC623611,NSC-623611,NSC 623611

Broparestrol (E)-

Cat.No: T9586

Target: Others

Prostaglandin F2β

Cat.No: T36621

15(S)-15-methyl Prostaglandin D2

Cat.No: T36153

Synonym: 15(S)-15-methyl Prostaglandin D2

Prostaglandin F2α 1,11-lactone

Cat.No: T37326

Synonym: Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone

Target: Prostaglandin Receptor

Azacosterol hydrochloride

Cat.No: T71133

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

Cat. No.	Product Name	Target	Signaling Pathways
T20217	Grandiflorenic acid
	Grandiflorenic acid can reproduce the uterine responses induced by aqueous extract of zoapatle leaves. It is suggested that grandiflorenic acid may have an antifertility effect.
TN1890	Lupeol acetate	Others; TNF; NOS	Apoptosis; Immunology/Inflammation; Others
	Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone.
TN3426	Anwuweizonic acid	Others	Others
	Anwuweizonic acid may have inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. Mixture of coccinic acid and anwuweizonic acid has antifertility activity, shows significant inhibitory activity against human decidu
TN3686	Coccinic acid	Others	Others
	Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual cells and rat luteal cells in vitro
TN5222	Vasicinol	Others	Others
	Vasicinol shows a high sucrase inhibitory activity, and the IC50 values was 250 μM.vasicinol could be an useful treatment for metabolic disorders.Vasicinol and vasicinone severe antifertility effects are exhibited by vasicinol against Dysdercus skoenigii

天然产物

Grandiflorenic acid

Cat.No: T20217

Cat.No: TN1890

Target: Others, TNF, NOS

Anwuweizonic acid

Cat.No: TN3426

Target: Others

Cat.No: TN3686

Target: Others

Cat.No: TN5222

Target: Others

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