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11

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25450	GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB; Rho	Cell Cycle/Checkpoint; NF-κB
	GGTI 2147 降低 Rac1 活性，下调 p65 的表达，改善 OGD/R 诱导的神经元凋亡。
T29090	Valibose
	Valibose An α-glucosidase inhibitor. Valibose ameliorated metabolic disturbance of glucose and lipids. valibose markedly reduced level of serum BUN and NAG, and decreased the weight index of kidney.
T70027	Eprociclovir potassium
	Eprociclovir potassium is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinica...
T28653	S-8510 free base SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510
	S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced
T61992	SIK1 activator 1
	SIK1 activator 1可以增强SIK1磷酸化和改善2型糖尿病小鼠的高血糖状态。SIK1 activator 1显示出显著抑制肝脏糖异生的活性。
T72034	LI-2242	Others	Others
	LI-2242是一种强效肌醇六磷酸激酶（IP6K）抑制剂，对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达，改善了肝脏脂肪变性，增强体外脂肪细胞和肝细胞的线粒体耗氧率（OCR）和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。
T69451	R-130823
	R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated ...
T69817	Eprociclovir Na
	Eprociclovir Na is the salt form of Eprociclovir, also known as A-5021, a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applie...
T63549	MRGPRX1 agonist 4
	MRGPRX1 agonist 4 是有效的、口服具有活力的 Mas 相关 G 蛋白偶联受体 X1 (MRGPRX1)正向变构调节剂 (EC50: 0.1 μM)。MRGPRX1 agonist 4 表现出良好的代谢稳定性以及口服生物利用度。MRGPRX1 agonist 4 能够改善人源性 MRGPRX1 神经疼痛模型小鼠行为性热过敏反应。
T68957	Eprociclovir dihydrate
	Eprociclovir dihydrate is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinica...
PDK0269	1-Phenylbiguanide HCl Phenylbiguanide hydrochloride
	Compound PDK0269作为5-HT3受体激动剂(3-100 μM, pEC50 5.05±0.06)，可急性增加XII(舌下)发作频率和规律性，并降低发作/次。Phenylbiguanide 产生剂量依赖性(10-500 μM)的多巴胺释放增加(280-2000%)。当Ringer 溶液中加入5 μM 的 nomifensine 时，Compound PDK0269对多巴胺释放的影响得到改善或抑制。

化合物

Cat.No: T25450

Synonym: GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147

Target: NF-κB, Rho

Cat.No: T29090

Eprociclovir potassium

Cat.No: T70027

S-8510 free base

Cat.No: T28653

Synonym: SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510

SIK1 activator 1

Cat.No: T61992

Cat.No: T72034

Target: Others

Cat.No: T69451

Eprociclovir Na

Cat.No: T69817

MRGPRX1 agonist 4

Cat.No: T63549

Eprociclovir dihydrate

Cat.No: T68957

1-Phenylbiguanide HCl

Cat.No: PDK0269

Synonym: Phenylbiguanide hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T5575	Cycloastragenol 环黄芪醇,Cyclogalegenol,Astramembrangenin	Epigenetic Reader Domain; Telomerase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Cycloastragenol (Astramembrangenin) 是一种三萜皂苷类化合物，是黄芪主要活性成分的水解产物，具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂，可以延长端粒，还能缓解与年龄相关的骨丢失，改善骨微结构和生物力学特性。
T6S1653	Albiflorin Alibiflorin,芍药内酯苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分，是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。
T6S2227	Spinosin 斯皮诺素,Flavoayamenin	Others	Others
	Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮，从 Zizyphus jujube 种子分离得到，能够激活 Nrf2/HO-1 通路，并抑制 Aβ1-42的产生和聚合。
T10554	Bixin	Others	Others
	Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and ROS generation.

天然产物

Cycloastragenol

Cat.No: T5575

Synonym: 环黄芪醇,Cyclogalegenol,Astramembrangenin

Target: Epigenetic Reader Domain, Telomerase

Cat.No: T6S1653

Synonym: Alibiflorin,芍药内酯苷

Target: Reactive Oxygen Species

Cat.No: T6S2227

Synonym: 斯皮诺素,Flavoayamenin

Target: Others

Cat.No: T10554

Target: Others

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