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8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39876 |
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride |
||
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride consists of a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker, making it suitable for PROTACs design. | |||
T18306 |
MC-Alkyl-Hydrazine Modified MMAF
|
Others | Others |
MC-Alkyl-Hydrazine Modified MMAF is a potent antitumor drug-linker conjugate for ADC, incorporating Modified MMAF, a tubulin inhibitor, through a noncleavable MC-Alkyl-Hydrazine linkage[1]. | |||
T18391 |
N-Boc-4-pentyne-1-amine
|
Others; PROTAC Linker | Others; PROTAC |
N-Boc-4-pentyne-1-amine 是一种基于烷基链的PROTAC连结剂,用于PROTAC MG-277[1]的合成。 | |||
T17694 |
Br-C10-methyl ester
11-溴代十一烷酸甲酯 |
Others; PROTAC Linker | Others; PROTAC |
Br-C10-methyl ester 是一种属于 alkyl/ether 类的 PROTAC linker,可用于一系列 PROTAC 分子的合成。PROTAC 分子含有两个通过 linker 连接的不同配体,一种是 VHL 配体部分,另一种是靶蛋白配体。 | |||
T18485 |
NH2-C4-NH-Boc
N-叔丁氧羰基-1,4-丁二胺 |
Others; PROTAC Linker | Others; PROTAC |
NH2-C4-NH-Boc 是一种属于 Alkyl/ether 类的 PROTAC linker,可用于一系列 PROTAC 分子的合成。 | |||
T40030 |
Thalidomide 4'-ether-alkylC2-amine hydrochloride
halidomide-linker 6 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker,是合成的 E3 连接酶配体-linker 偶联物,可应用于 PROTAC 技术。 | |||
T0604 |
Desalkylterbuthylazine
|
Others | Others |
Desalkylterbuthylazine 用作医药中间体。 | |||
T36279 |
VH 032 amide-alkylC3-amine
VH 032 amide-alkylC3-amine |
||
Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl C3 linker and terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36282 |
VH 032 amide-alkylC7-amine
VH 032 amide-alkylC7-amine |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36270 |
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride
VH 032 phenol-alkylC6-amine |
||
Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 2 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36281 |
VH 032 amide-alkylC5-amine
VH 032 amide-alkylC5-amine |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 13 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36276 |
Thalidomide 4'-oxyacetamide-alkylC8-amine
Thalidomide 4'-oxyacetamide-alkylC8-amine |
||
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide amide-alkylC8-amine PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36277 |
VH 032 amide-alkylC2-acid
VH 032 amide-alkylC2-acid |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus alkylC2 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36273 |
VH 101 phenol-alkylC4-amine
VH 101 phenol-alkylC4-amine |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36278 |
VH 032 amide-alkylC3-acid
VH 032 amide-alkylC3-acid |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for research and development; incorporates an E3 ligase ligand plus alkylC3 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules. | |||
T36263 |
Pomalidomide 4'-alkylC8-acid
Pomalidomide 4'-alkylC8-acid |
||
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T83961 |
Thalidomide 5'-amine-alkylC6-amine
|
||
Thalidomide 5'-amine-alkylC6-amine是用于PROTAC研究与开发的功能化cereblon配体;包含一个E3连接酶配体和一个带有末端胺基的alkylC6连接器,用于与目标蛋白配体的结合。这是一系列用于PROTAC研发的功能化工具分子之一。 | |||
T36280 |
VH 032 amide-alkylC4-acid
VH 032 amide-alkylC4-acid |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus alkylC4 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 5 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T83954 |
VH 032 amide-alkylC7-acid
(S,R,S)-AHPC-amido-C7-acid |
||
VH 032 amide-alkylC7-acid 是一种用于PROTAC研究与开发的功能化Von-Hippel-Lindau蛋白配体(VHL),结合了E3连接酶配体和具有末端羧酸的alkylC7连接物,便于与目标蛋白配体偶联。该化合物是为PROTAC研发设计的一系列功能化工具分子之一。 | |||
T74372 | N-Desalkyludenafil | ||
N-Desalkyludenafil 是 Udenafil 的代谢物。Udenafil 是一种PDE5抑制剂,用于研究勃起功能障碍。 | |||
T40053 |
Boc-A 410099.1 amide-alkylC4-amine
Boc-A 410099.1 amide-alkylC4-amine |
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Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTACs, comprising of an IAP ligand and an amide-alkylC4 linker terminating in an amine group. It has the ability to form conjugates with target protein ligands. | |||
T36274 |
VH 101 phenol-alkylC6-amine
VH 101 phenol-alkylC6-amine |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC6 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T34865 |
Thyminalkylamine
|
||
Thyminalkylamine is a biochemical. | |||
T35469 |
A 410099.1 amide-alkylC4-amine
A 410099.1 amide-alkylC4-amine |
||
Functionalized IAP ligand for PROTAC research and development; incorporates an IAP ligand plus an amide-alkylC4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36283 |
VH 032 amide-alkylC8-acid
VH 032 amide-alkylC8-acid |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus alkylC8 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T36250 |
Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine |
||
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC1-PEG3-alkylC3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T20331 |
Sodium lauroyl glutamate
Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11 |
Others | Others |
Sodium lauroyl glutamate (Acylglutamate LS-11) 是一种氨基酸去污剂,可增加长链没食子酸烷基酯(如没食子酸烷基酯)的溶解度。 | |||
T17323 |
11-Aminoundecanoic acid
|
Others; PROTAC Linker | Others; PROTAC |
11-Aminoundecanoic acid 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T38543 |
5-(Biotinamido)pentylamine
|
PROTAC Linker | PROTAC |
5-(Biotinamido)pentylamine 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。 | |||
T17638 |
Boc-11-aminoundecanoic acid
|
Others; PROTAC Linker | Others; PROTAC |
Boc-11-aminoundecanoic acid 是一种属于 Alkyl/ether 类的 PROTAC linker,可用于 MS432 的合成。 | |||
T18513 |
OTs-C6-OBn
|
Others; PROTAC Linker | Others; PROTAC |
OTs-C6-OBn 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC SGK3 degrader-1 的合成。 | |||
T19982 |
Tralkoxydim
三甲苯草酮,Splendor,Tralkoxydime |
Acetyl-CoA Carboxylase | Metabolism |
Tralkoxydim (Tralkoxydime) 是一种烷基酮类除草剂。 Tralkoxydim 用作 ACCase 抑制剂。 | |||
T14185 |
Alkynyl Palmitic Acid
|
Others; PROTAC Linker | Others; PROTAC |
Alkynyl Palmitic Acid 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17549 |
Biotin-EDA
|
Others; PROTAC Linker | Others; PROTAC |
Biotin-EDA 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17652 |
Boc-NH-C12-NH2
(12-氨基十二烷基)氨基甲酸叔丁酯 |
Others; PROTAC Linker | Others; PROTAC |
Boc-NH-C12-NH2 是一种属于 alkyl/ether 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17324 |
11-Maleimidoundecanoic acid
|
Others; PROTAC Linker | Others; PROTAC |
11-Maleimidoundecanoic acid 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T14060 |
6-Maleimidocapronic acid
|
PROTAC Linker | PROTAC |
6-Maleimidocapronic acid 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T18546 |
(+)-Biotin-ONP
(+)-生物素对硝基苯酯,(+)-Biotin 4-nitrophenyl ester |
Others; PROTAC Linker | Others; PROTAC |
(+)-Biotin-ONP ((+)-Biotin 4-nitrophenyl ester) 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17655 |
Boc-NH-O-C1-NHS ester
[(叔丁氧羰基氨基氧]乙酸N-琥珀酰亚胺酯 |
Others; PROTAC Linker | Others; PROTAC |
Boc-NH-O-C1-NHS ester 是一种属于 alkyl/ether 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17321 |
1,3-Dibromo-5,5-dimethylhydantoin
|
Others; PROTAC Linker | Others; PROTAC |
1,3-Dibromo-5,5-dimethylhydantoin 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17348 |
Ac4GalNAz
|
Others; PROTAC Linker | Others; PROTAC |
Ac4GalNAz 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T15069 |
DBCO-PEG4-Biotin
ADIBO-NH-PEG2-Biotin |
Others | Others |
DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) 是一种 azadibenzocyclooctyne-biotin 衍生物,含有生物素基团和 4 个 PEG。DBCO-PEG4-Biotin 是一种用途广泛的生物素酰化试剂,能通过无铜催化烷基叠氮化反应 (SPAAC) 将生物素的一部分引入叠氮标记的生物分子中。 | |||
T14408 |
Azido-PEG1-CH2CO2H
4-哌啶酮缩乙二醇 |
Others; PROTAC Linker | Others; PROTAC |
Azido-PEG1-CH2CO2H 是属于 alkyl/ether 类的PROTAC linker,可用于合成 PROTAC BRD4 Degrader-1. | |||
T41090 |
L-Azidohomoalanine hydrochloride
H-L-Aha-OH hydrochloride |
PROTAC Linker | PROTAC |
L-Azidohomoalanine hydrochloride (H-L-Aha-OH hydrochloride) 是一种基于烷基链的 PROTAC 接头。 | |||
T17330 |
2-Phthalimidehydroxy-acetic acid
|
Others; PROTAC Linker | Others; PROTAC |
2-Phthalimidehydroxy-acetic acid 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17548 |
Biotin-C5-amino-C5-amino
|
Others; PROTAC Linker | Others; PROTAC |
Biotin-C5-amino-C5-amino 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17014 |
TCO-NHS ester
|
Others; PROTAC Linker | Others; PROTAC |
TCO-NHS ester 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。 | |||
T18616 |
NH2-C2-NH-Boc
PROTAC Linker 22,N-叔丁氧羰基-1,2-乙二胺 |
Others; PROTAC Linker | Others; PROTAC |
NH2-C2-NH-Boc (PROTAC Linker 22) 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T2492 |
Perifosine
NSC 639966,D21266,KRX-0401,哌立福新 |
Apoptosis; Akt; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Perifosine (KRX-0401) 是一种具有口服活性的烷基磷酸胆碱 Akt 抑制剂,具有抗肿瘤活性。 | |||
T18617 |
NH2-C5-NH-Boc
N-(5-氨基戊基)氨基甲酸叔丁酯,PROTAC Linker 23 |
Others; PROTAC Linker | Others; PROTAC |
NH2-C5-NH-Boc (PROTAC Linker 23) 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3751 |
2',4'-Dihydroxyacetophenone
Resacetophenone,雷琐乙酰苯,1-(2,4-Dihydroxyphenyl)ethanone,2,4-Dihydroxyacetophenone,4-Acetylresorcinol |
Others; Endogenous Metabolite | Metabolism; Others |
2',4'-Dihydroxyacetophenone (Resacetophenone) 是一种植物代谢物,是在2'和4'位置被羟基取代基的苯乙酮。。 | |||
T8307 |
Hydroxy-α-sanshool
羟基-α-山椒素,Hydroxy-α-sanshool |
Endogenous Metabolite; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Hydroxy-α-sanshool 是分离自胡椒的烷基酰胺,作为 TRPA1的共价激动剂和 TRPV1的非共价激动剂,EC50分别为69和 1.1 µM。 | |||
T9784 |
Docosanedioic acid
|
PROTAC Linker | PROTAC |
Docosanedioic acid 可以作为ADC linker 或PROTAC linker,用于合成抗体偶联药物或合成 PROTAC。 | |||
T2821 |
Ethyl ferulate
Ethyl 4'-hydroxy-3'-methoxycinnamate,Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate,阿魏酸乙酯,Ferulic acid ethyl ester,乙基阿魏酸 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Ethyl ferulate (Ethyl 4'-hydroxy-3'-methoxycinnamate) 是一种从大茴香分离得到的阿魏酸的天然亲酯衍生物,能够诱导血红素氧合酶 1 ,保护大鼠神经元免受氧化应激。它能够保护神经元,使其受 β 淀粉样肽(1-42)导致的全身性的氧化应激和神经毒性。 | |||
T16223 |
N-Dodecyl-β-D-maltoside
十二烷基-β-D-麦芽糖苷,Lauryl Maltoside |
Others | Others |
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) 是一种芘 (Py) 的衍生物。它可用作烷基吡喃麦芽糖苷清洁剂,尤其是在转运蛋白和呼吸复合物中。它已用于诸如 RNA 聚合酶的纯化和稳定化,以及蛋白质-脂质相互作用的检测的应用中。 | |||
TN1979 |
Neocnidilide
新蛇床内酯,新蛇床内酯,新川芎内酯 |
Antifungal | Microbiology/Virology |
Neocnidilide 是一种从川芎中提取的烷基邻苯二甲酸酯,具有抑制产生真菌毒素的真菌生长和杀虫。Neocnidilide 对 D. melanogaster 幼虫的LC50 值为 9.9 μmol/mL。它可以增强苯甲酸的皮肤渗透性。 | |||
T13732 |
Hydroxy-Epsilon-Sanshool
|
Others | Others |
Hydroxy-Epsilon-Sanshool is an alkyl amide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensation. | |||
T0665 |
Xanthine
2,6-Dihydroxypurine,海生丁(黄嘌呤),黄嘌呤,Isoxanthine |
Endogenous Metabolite; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Xanthine (Isoxanthine) 是一种植物生物碱,存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂,也是嘌呤降解途径的中间产物。 |