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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T37416 Tauro-α-muricholic Acid (sodium salt)

Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but has also been found in small amounts in human serum.
T63793 Tauro-ω-muricholic acid sodium

Tauro-ω-muricholic acid sodium (TωMCA sodium) 是一种tauro-α-muricholic acid 的类似物,是来源于肝脏的胆汁酸。Tauro-ω-muricholic acid sodium 能用作早发性新生儿败血症 (EOS) 和胆汁淤积的血清标志物。
T13093 Tauro-β-muricholic acid sodium

T-βMCA sodium

FXR Metabolism
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).

化合物

Tauro-α-muricholic Acid (sodium salt)
Cat.No: T37416
Synonym:
Target:
Tauro-ω-muricholic acid sodium
Cat.No: T63793
Synonym:
Target:
Tauro-β-muricholic acid sodium
Cat.No: T13093
Synonym: T-βMCA sodium
Target: FXR
Cat. No. Product Name Target Signaling Pathways
T19623 α-Muricholic acid

AChR Neuroscience
α-Muricholic acid is the most abundant primary bile acid in rodents.
T40790 ω-Muricholic Acid

ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.
T81030 Tauro-β-muricholic acid

TβMCA

FXR Metabolism
Tauro-β-muricholic acid (TβMCA) 为一种具有三羟基结构的胆汁酸,是FXR的竞争性、可逆拮抗剂,IC50值为40 μM。此外,Tauro-β-muricholic acid 能够通过维持线粒体膜电位来阻抑胆汁酸引起的肝细胞凋亡,发挥抗凋亡功能。
T37997 Murideoxycholic Acid

Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.[3],[4] Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl ...
T35400 β-Muricholic Acid

β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid

β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

天然产物

α-Muricholic acid
Cat.No: T19623
Synonym:
Target: AChR
ω-Muricholic Acid
Cat.No: T40790
Synonym:
Target:
Tauro-β-muricholic acid
Cat.No: T81030
Synonym: TβMCA
Target: FXR
Murideoxycholic Acid
Cat.No: T37997
Synonym:
Target:
β-Muricholic Acid
Cat.No: T35400
Synonym: β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid
Target:
TargetMol Loading
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