Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2154 |
MG-132
Z-LLL-al,Z-Leu-Leu-Leu-CHO |
Apoptosis; Proteasome; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM),具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂,可诱导凋亡。 | |||
T78640 |
Z-LLF-CHO
Z-Leu-Leu-Phe-CHO |
Proteasome | Proteases/Proteasome; Ubiquitination |
Z-LLF-CHO(Z-Leu-Leu-Phe-CHO)为垂体多催化蛋白酶复合物所具有的胰凝乳蛋白酶样活性提供有效抑制,具有Ki值为460 nM。此外,Z-LLF-CHO同样作为NF-κB核转位的抑制剂。 | |||
T17281 |
Z-Ile-Leu-aldehyde
Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII |
Others | Others |
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch. | |||
T80735 |
Z-Gly-Pro-Phe-Leu-CHO
Z-GPFL-CHO |
Proteasome | Proteases/Proteasome; Ubiquitination |
Z-Gly-Pro-Phe-Leu-CHO(Z-GPFL-CHO)是一种具有高选择性和高效率的四肽醛类蛋白酶体抑制剂,优先抑制支链氨基酸(Ki为1.5 µM),对小中性氨基酸的Ki值为2.3 µM,胰凝乳蛋白酶样活性的Ki值为40.5 µM,对肽基-谷氨酰肽水解活性的IC50为3.1 µM。 |