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4

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T6798 Tretazicar

5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829

DNA Alkylator/Crosslinker; DNA Alkylation DNA Damage/DNA Repair
Tretazicar (NSC-115829) 是一种抗肿瘤前药,由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂,可以形成 DNA-DNA 链间交联。
T24644 Piritrexim

BW 301U

DHFR Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
Piritrexim (BW 301U) 是一种可口服的脂溶性二氢叶酸还原酶抑制剂,具有肺毒性,用于研究尿路上皮癌和转移性乳腺癌。
T83544 (E)-5-Octadecene

(E)-Octadec-5-ene

(E)-Octadec-5-ene ((E)-5-Octadecene),作为一种性信息素或相关化学物质,能够抑制Chilo suppressalis Walker(水稻螟虫蛾)雌蛾的性吸引力。
T36701 Phosphoramide mustard (cyclohexanamine)

Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce...

化合物

Tretazicar
Cat.No: T6798
Synonym: 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Piritrexim
Cat.No: T24644
Synonym: BW 301U
Target: DHFR
(E)-5-Octadecene
Cat.No: T83544
Synonym: (E)-Octadec-5-ene
Target:
Phosphoramide mustard (cyclohexanamine)
Cat.No: T36701
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T3S1955 7-Ethylcamptothecin

Others Others
7-Ethylcamptothecin 是一种喜树碱类似物。其中喜树碱是一种细胞毒性生物碱,从喜树中分离出得到,对 L1210 白血病和 Walker 256 癌肉瘤模型具有很强的抗肿瘤活性。

天然产物

7-Ethylcamptothecin
Cat.No: T3S1955
Synonym:
Target: Others
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