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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6798 |
Tretazicar
5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Tretazicar (NSC-115829) 是一种抗肿瘤前药,由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂,可以形成 DNA-DNA 链间交联。 | |||
T24644 |
Piritrexim
BW 301U |
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Piritrexim (BW 301U) 是一种可口服的脂溶性二氢叶酸还原酶抑制剂,具有肺毒性,用于研究尿路上皮癌和转移性乳腺癌。 | |||
T83544 |
(E)-5-Octadecene
(E)-Octadec-5-ene |
||
(E)-Octadec-5-ene ((E)-5-Octadecene),作为一种性信息素或相关化学物质,能够抑制Chilo suppressalis Walker(水稻螟虫蛾)雌蛾的性吸引力。 | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S1955 |
7-Ethylcamptothecin
|
Others | Others |
7-Ethylcamptothecin 是一种喜树碱类似物。其中喜树碱是一种细胞毒性生物碱,从喜树中分离出得到,对 L1210 白血病和 Walker 256 癌肉瘤模型具有很强的抗肿瘤活性。 |