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Cat. No. | Product Name | Target | Signaling Pathways |
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T37406 |
Apovincaminic acid hydrochloride salt
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Apovincaminic acid hydrochloride salt, the primary active metabolite of Vinpocetine (VP), is orally active and has the ability to penetrate the brain. It demonstrates a neuroprotective mechanism of action [1][2]. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0167 |
Vinpocetine
长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate |
IκB/IKK; NF-κB; Sodium Channel; PDE | Membrane transporter/Ion channel; Metabolism; NF-κB |
Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物,是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂,并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应,已被广泛用于研究脑血管疾病。 | |||
T21047 |
Apovincamine
cis-Apovincamine |
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Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity. |