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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12306 |
OMDM-5
|
Cannabinoid Receptor; Endogenous Metabolite; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
OMDM-5 是有效的、选择性的anandamide 细胞摄取抑制剂,Ki 为 4.8 μM。它是VR1 (TRPV1)激动剂,EC50为 75 nM,显示出对大麻素 1 型受体 (CB1) 的弱配体活性 (Ki=4.9 μM)。 | |||
T12302 |
OMDM-1
(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide |
Endogenous Metabolite | Metabolism |
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) 是有效选择性的代谢稳定 anandamide 细胞摄取抑制剂,Ki=为2.4 μM。 | |||
T6977 |
SB-366791
SB366791 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB366791 是一种有效的 vanilloid receptor (VR1/TRPV1)选择性拮抗剂 (IC50=5.7 nM)。SB-366791 在炎症方面有研究价值。 | |||
T22515 |
5'-Iodoresiniferatoxin
|
Others | Others |
TRPV1 (VR1) receptor antagonist | |||
T22527 | 6'-Iodoresiniferatoxin | Others | Others |
TRPV1 (VR1) vanilloid receptor partial agonist | |||
T75830 |
L-R4W2 TFA
|
||
L-R4W2 TFA,作为一种有效的香草酸受体1 (VR1,TRPV1) 拮抗剂,其IC50值达到0.1 μM,主要用于疼痛缓解的研究。 | |||
T22586 |
Arvanil
|
Others | Others |
Cannabinoid CB1 and vanilloid TRPV1 (VR1) agonist | |||
TP1934 |
L-R4W2
|
||
Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo. | |||
T23178 |
PPAHV
|
Others | Others |
vanilloid TRPV1 (VR1) receptor agonist | |||
T69274 |
DD-161515
|
||
DD-161515 is a VR1 antagonist. | |||
T76369 |
CEDAEVFKDSMVPGEK
|
||
CEDAEVFKDSMVPGEK 为大鼠辣椒素受体亚型 1 (VR1) 的多肽序列片段,适用于探测 VR1 的存在、分布及分子形态。 | |||
T37668 |
CAY10448
CAY10448 |
||
Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Capsaicin signals are transduced by a heat-activated ion channel, the vanilloid receptor 1 (VR1), or transient receptor potential vanilloid 1 (TRPV1). CAY10448 is an iodinated nonivamide, a potent capsaicin receptor antagonist with an IC50 value of approximately 10 nM. | |||
T37216 |
N-Arachidonoyl-L-Alanine
|
||
Several different arachidonoyl amino acids, including N-arachidonoyl-L-alanine (NALA), have been isolated and characterized from bovine brain. The glycine congener (NAGly) was further characterized and found to suppress formalin-induced pain in rats. NALA may have activity at cannabinoid receptor and/or VR1, but has not been fully characterized to date. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 |