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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T21303 Etoposide Phosphate

Eposin Etopophos Vepesid VP16,磷酸依托泊苷

Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell proliferation.
T69162 Ki23057

Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism betwee...

化合物

Etoposide Phosphate
Cat.No: T21303
Synonym: Eposin Etopophos Vepesid VP16,磷酸依托泊苷
Target:
Ki23057
Cat.No: T69162
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T0132 Etoposide

VP-16,依托泊苷,依托泊甙,VP-16-213

Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology
Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性,可以诱导细胞凋亡、自噬。

天然产物

Etoposide
Cat.No: T0132
Synonym: VP-16,依托泊苷,依托泊甙,VP-16-213
Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy
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