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Cat. No.	Product Name	Target	Signaling Pathways
T13232	TyK2-IN-2	PDE	Metabolism
	TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
T13237L	Ropsacitinib Tyk2-IN-8,PF-06826647	Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Ropsacitinib (PF-06826647) 是一种选择性TYK2抑制剂。Ropsacitinib 与Tyk2催化活性JH1结构域结合(IC50:17nM)。
T13234	Tyk2-IN-5	Others	Others
	Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
T13237	Tyk2-IN-9	Others	Others
	Tyk2-IN-9 (化合物26)，作为一种高选择性Tyk-2抑制剂，展现出对TYK2-JH2的IC50为0.076 nM，及对JAK1-JH2的IC50为1.8 nM，显示其在炎症或自身免疫性疾病研究中的应用前景。
T13233	Tyk2-IN-3	Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
T13235	Tyk2-IN-7	Others	Others
	Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).
T22416	RO495 CS-2667	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	RO495 (CS-2667) 是一种有效的非受体酪氨酸蛋白激酶2抑制剂。
T63146	JAK2/TYK2-IN-1
	JAK2/TYK2-IN-2 是一种有效的、选择性的 TYK2 (IC50: 9 nM) 和 JAK2 (IC50: 157 nM) 抑制剂，具有抗炎作用。
T62451	TYK2-IN-12
	TYK2-IN-12 (compound 30) 是一种选择性的、口服具有活力的 TYK2 (酪氨酸激酶 2) 抑制剂 (Ki: 0.51 nM)。TYK2-IN-12 对 IL-12 诱导的人和小鼠全血中 IFNγ 具有抑制作用，他们的 IC50 值分别为 2.7 和 7.0 μM。TYK2-IN-12 能够用于研究银屑病。
T61658	TYK2-IN-11
	TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1].
T83218	ABBV-712	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	ABBV-712为选择性酪氨酸激酶 2 (TYK2) 抑制剂，IC50值为0.195 μM，关键作用于自身免疫性疾病。
T70394	Deucravacitinib HCl
	Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp...
T79235	JAK-IN-30	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-30（化合物31）是一种具有水溶性的JAK抑制剂，对JAK2、JAK1、JAK3及TYK2的IC50值分别为2、15、18及2 nM。该化合物作为研究干眼症（DED）的潜在药物而备受关注。

化合物

Cat.No: T13232

Target: PDE

Cat.No: T13237L

Synonym: Tyk2-IN-8,PF-06826647

Target: Tyrosine Kinases

Cat.No: T13234

Target: Others

Cat.No: T13237

Target: Others

Cat.No: T13233

Target: Tyrosine Kinases

Cat.No: T13235

Target: Others

Cat.No: T22416

Synonym: CS-2667

Target: Tyrosine Kinases, JAK

JAK2/TYK2-IN-1

Cat.No: T63146

Cat.No: T62451

Cat.No: T61658

Cat.No: T83218

Target: JAK

Deucravacitinib HCl

Cat.No: T70394

Cat.No: T79235

Target: JAK

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