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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T5150	Treprostinil LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil (Orenitram) 是有效的 DP1、IP 和 EP2 激动剂，EC50分别为0.6、1.9 和 6.2 nM。
T5171	Treprostinil Sodium 曲前列尼尔钠,UT-15	VEGFR; c-RET; Prostaglandin Receptor	Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Treprostinil Sodium (UT-15) 是有效的 DP1、IP 和 EP2 激动剂，EC50分别为0.6、1.9 和 6.2 nM。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T39165	Treprostinil palmitil Treprostinil palmitil,INS-1009
	Treprostinil Palmitil (TP), a prodrug of the DP1 and EP2 agonist Treprostinil (UT-15), exhibits EC50 values of 0.6 and 6.2 nM, respectively. It is a pure prodrug without any inherent binding affinity for G-protein coupled receptors, including prostanoid receptors.
T36210	15-keto Treprostinil (sodium salt)
	15-keto Treprostinil is an impurity found in treprostinil , which is a stable analog of prostaglandin I2 with a longer plasma half-life. Formulations containing treprostinil are used for the treatment of primary pulmonary hypertension.

化合物

Treprostinil

Cat.No: T5150

Synonym: LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin

Target: Prostaglandin Receptor

Treprostinil Sodium

Cat.No: T5171

Synonym: 曲前列尼尔钠,UT-15

Target: VEGFR, c-RET, Prostaglandin Receptor

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Treprostinil palmitil

Cat.No: T39165

Synonym: Treprostinil palmitil,INS-1009

Target:

15-keto Treprostinil (sodium salt)

Cat.No: T36210

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN7246	3-Sulfopropanoic acid 3-SPA	Drug Metabolite	Metabolism
	3-Sulfopropanoic acid 是曲吡罗酯及其前药ALZ-801的主要代谢产物，是存在于AD患者的脑脊液（CSF）中的内源性分子，可抑制 Aβ42 寡聚体的形成。