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Cat. No.	Product Name	Target	Signaling Pathways
T6708	Tolcapone Tasmar,Ro 40-7592,托卡朋	Apoptosis; Beta Amyloid; Transferase	Apoptosis; Metabolism; Neuroscience
	Tolcapone (Ro 40-7592) 是一种选择性，具有口服活性的外周和中枢COMT 抑制剂，在肝脏中对 COMT 的IC50为 773 nM。它还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可诱导氧化应激导致神经母细胞瘤细胞凋亡和抑制肿瘤生长。
T13181	Tolcapone D7 Ro 40-7592 D7	Transferase	Metabolism
	Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
T10119	3-O-Methyltolcapone Ro 40-7591	Transferase	Metabolism
	3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease.
T10118	3-O-Methyltolcapone D7 Ro 40-7591 D7	Transferase	Metabolism
	3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P
T28593	Ro 61-1448 Ro-61-1448,Ro 611448
	Ro 61-1448 is a metabolite of tolcapone, a catechol-O-methyltransferase inhibitor.
T11207	Entacapone sodium salt	Others	Others
	Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catech...

化合物

Cat.No: T6708

Synonym: Tasmar,Ro 40-7592,托卡朋

Target: Apoptosis, Beta Amyloid, Transferase

Cat.No: T13181

Synonym: Ro 40-7592 D7

Target: Transferase

3-O-Methyltolcapone

Cat.No: T10119

Synonym: Ro 40-7591

Target: Transferase

3-O-Methyltolcapone D7

Cat.No: T10118

Synonym: Ro 40-7591 D7

Target: Transferase

Cat.No: T28593

Synonym: Ro-61-1448,Ro 611448

Entacapone sodium salt

Cat.No: T11207

Target: Others

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