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Cat. No. | Product Name | Target | Signaling Pathways |
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T29017 |
TrxR1-IN-B19
TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015 |
Others | Others |
TrxR1-IN-B19 (TrxR1 IN B19) 是一种 TrxR1 抑制剂,通过靶向 TrxR1 和 ROS 介导的 ER 应激激活,通过小分子选择性杀死胃癌细胞。 | |||
T78781 |
TrxR1-IN-1
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TrxR1-IN-1 (Compound 5j) 是一种具有针对性的TrxR1抑制剂,显示出IC50值为8.8 μM的抑制效能。该化合物在治疗癌症方面表现出潜在效果,其对多种癌细胞系的IC50值分别为:MCF-7细胞系1.5 μM、HeLa细胞系1.7 μM、BGC-823细胞系2.4 μM、SW-480细胞系2.8 μM和 A549细胞系2.1 μM。此外,TrxR1-IN-1还表现出了抗氧化特性,能有效清除DPPH自由基。 | |||
T4414 |
Eprenetapopt
APR-246,PRIMA-1Met |
Apoptosis; Others; Ferroptosis; p53; Autophagy | Apoptosis; Autophagy; Others |
Eprenetapopt (PRIMA-1Met) 是一种在 TP53突变细胞中恢复野生型 p53功能的小分子,可引发肿瘤细胞凋亡,还抑制硒蛋白硫氧还蛋白还原酶 1。 | |||
T39664 |
Ethaselen
BBSKE |
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Ethaselen (BBSKE), a selective thioredoxin reductase (TrxR) inhibitor, is orally active with IC50s of 0.5 and 0.35 μM for wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair located in the C-terminal active site of mammalian TrxR1. As an organoselenium compound, it demonstrates potent antitumor activity against non-small cell lung cancer (NSCLC) by targeting TrxR. | |||
T11130 | DVD-445 | Others | Others |
Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M. | |||
T14351 |
Aurothioglucose
Gold thioglucose,金硫葡萄糖 |
Others | Others |
Aurothioglucose is a active-site TrxR1 inhibitor. | |||
T73512 | ZC0109 | ||
ZC0109 是 IDO1和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂,IC50分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累,使细胞周期阻滞于 G1/S 期,导致癌细胞凋亡 (apoptosis)。 | |||
T73547 | CPUL1 | ||
CPUL1 是一种TrxR 抑制剂,对 A549 细胞显示出增殖抑制和抗转移活性。CPUL1 通过抑制TrxR1酶活性来诱导 ROS 介导的ERK/JNK 信号传导从而影响上皮-间质转化 (EMT)。CPUL1 与α-Lipoic Acid 或Dithiodipropionic acid 联合使用效果更好。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02271 |
TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)
thioredoxin reductase 1,TR1,TXNR,TR,TR... |
Human | E. coli |
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor th... |