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Cat. No. | Product Name | Target | Signaling Pathways |
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T26284 |
Tpl2-IN-I
Tpl2 inhibitor I,Tpl2-inhibitor-I,Tpl2 IN I,Tpl2 kinase inhibitor |
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Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase. | |||
T35536 |
Tpl2 Kinase Inhibitor (hydrochloride)
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Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5... | |||
T17145 |
Tpl2 Kinase Inhibitor 1
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Others | Others |
Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor. | |||
T10866 |
Cot inhibitor-2
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TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-2 是一种 cot (Tpl2/MAP3K8) 抑制剂(IC50 : 1.6 nM),具有有效性,选择性和口服活性。Cot inhibitor-2 对LPS 刺激的人全血中 TNF-α 的产生具有抑制作用,IC50 为 0.3 μM。 | |||
T10865 |
Cot inhibitor-1
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TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生,其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路,特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性,可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN1236 |
3',4',7-Trihydroxyisoflavone
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MAPK; JNK | MAPK |
3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物,是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂,具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用,可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能,可用于研究特应性皮炎。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-04389 |
MAP3K8 Protein, Human, Recombinant (GST)
TPL2,MEKK8,EST,ESTF,COT,Tpl-2... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the... |