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Search Results for " sphingolipids "

10

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T37954	Sphingosine (d20:1) Sphingosine (d20:1)
	Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mam...
T37457	C18 L-threo Ceramide (d18:1/18:0) C18 L-threo Ceramide (d18:1/18:0)
	C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM).
T38180	C16 Phytoceramide (t18:0/16:0)
	C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous ...
T38291	C24 Phytosphingosine (t18:0/24:0)
	C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t18:0/24:0) is composed of a phytosphingosine backbone amine-linked to a C24 fatty acid chain. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. In a stratum corneum model of healthy skin, the inco...
T36323	C8 Galactosylceramide (d18:1/8:0) C8 Galactosylceramide (d18:1/8:0)
	C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo....
T37953	Sphingomyelins (buttermilk)
	Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling...
T36054	D13
	D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. \|1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).
T37889	BHBM
	BHBM is an acylhydrazone with antifungal activity.1,2 It is active against C. neoformans in vitro (MIC80 = 1 μg/ml).2 BHBM (0.25, 1, and 4 μg/ml) inhibits the synthesis of glucosylceramide, which is essential to fungal cell division, in C. neoformans but not J774 murine macrophages.1 In vivo, BHBM (1.2 mg/kg per day) increases survival in a mouse model of C. neoformans infection. \|1. Haranahalli, K., Lazzarini, C., Sun, Y., et al. SAR studies on aromatic acylhydrazone-based inhibitors of fungal...
T38286	C26 Sphingomyelin (d18:1/26:0) C26 Sphingomyelin (d18:1/26:0)
	C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi...

化合物

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Sphingosine (d20:1)

Cat.No: T37954

Synonym: Sphingosine (d20:1)

C18 L-threo Ceramide (d18:1/18:0)

Cat.No: T37457

Synonym: C18 L-threo Ceramide (d18:1/18:0)

C16 Phytoceramide (t18:0/16:0)

Cat.No: T38180

C24 Phytosphingosine (t18:0/24:0)

Cat.No: T38291

C8 Galactosylceramide (d18:1/8:0)

Cat.No: T36323

Synonym: C8 Galactosylceramide (d18:1/8:0)

Sphingomyelins (buttermilk)

Cat.No: T37953

Cat.No: T36054

Cat.No: T37889

C26 Sphingomyelin (d18:1/26:0)

Cat.No: T38286

Synonym: C26 Sphingomyelin (d18:1/26:0)

Cat. No.	Product Name	Target	Signaling Pathways
T4761	Pyridoxal hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal hydrochloride 是内源性代谢产物的一种。
T0973L	Pyridoxine hydrochloride Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中，通过 Nrf-2/HO-1 途径发挥抗氧化作用。
T78473	Sphingosine (d17:1) C17 Sphingosine
	Sphingosine (d17:1) (C17 Sphingosine)是一种存在于人类皮肤中的17碳鞘脂，可被鞘氨醇激酶的磷酸化。Sphingosine C-17作为内标可用于进行鞘脂类化合物的光谱分析。
T4944	Nervonic acid cis-15-Tetracosenoic acid,神经酸,Selacholeic acid	Endogenous Metabolite	Metabolism
	Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。

天然产物

Pyridoxal hydrochloride

Cat.No: T4761

Target: Others, Endogenous Metabolite

Pyridoxine hydrochloride

Cat.No: T0973L

Synonym: Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6

Target: Nrf2, Endogenous Metabolite

Sphingosine (d17:1)

Cat.No: T78473

Synonym: C17 Sphingosine

Cat.No: T4944

Synonym: cis-15-Tetracosenoic acid,神经酸,Selacholeic acid

Target: Endogenous Metabolite

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

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