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Cat. No.	Product Name	Target	Signaling Pathways
T60765	STAT3-IN-10
	STAT3-IN-10 (A11) 是一种STAT3抑制剂，可直接结合 STAT3 SH2 结构域，抑制肿瘤细胞生长并且诱导肿瘤细胞凋亡 (IC 50 = 5.18 μM)。
T18680	SD-36	Others; PROTACs	Others; PROTAC
	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their transcriptional activity (IC50=10 nM). The compound, consisting of the STAT3 inhibitor SI-109, a linker, and a CRBN ligand Lenalidomide analog for E3 ubiquitin ligase[1], demonstrates significant anti-tumor effects and achieves complete, long-lasting tumor regression in mouse mod...
T6761	Ossirene AS101	IL Receptor; Caspase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ossirene (AS101) 是一种免疫调节抑制剂，是一种新型 IL-1beta 转化酶抑制剂，可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化，有效抑制Caspase-1。
T74733	OSM-SMI-10B
	OSM-SMI-10B，OSM-SMI-10的衍生物，与OSM (Oncostatin M) 共孵育时，可显著降低OSM诱导的癌细胞STAT3磷酸化。
T36645	CAY10763 CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM...
T36035	CAY10784
	CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2 1.Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway i...