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Cat. No. | Product Name | Target | Signaling Pathways |
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T12710 |
Retagliptin Phosphate
SP 2086,瑞格列汀磷酸盐 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Retagliptin Phosphate (SP 2086) 是一种选择性、竞争性、口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin phosphate 能够用于 2 型糖尿病 (T2DM) 的研究。 | |||
T7890 |
SP-13786
UAMC-1110,(S)-N-[2-(2-氰基-4,4-二氟-1-吡咯烷基)-2-氧代乙基]喹啉-4-甲酰胺 |
Others | Others |
SP-13786 (UAMC-1110) 是成纤维细胞活化蛋白 (FAP) 的抑制剂 (IC50 : 3.2 nM);还抑制脯氨酰寡肽酶 (PREP) ( IC50 : 1.8 μM)。 | |||
T34734 |
Substance P (1-4)
SP(1-4) |
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Substance P (1-4) is a substance P N-terminal tetrapeptide fragment. | |||
T66146 |
(SP-4-4)-2-[2-(Amino-KappaN)ethyl]phenyl-KappaC]chloro[dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine]-Palladium
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(SP-4-4)-2-[2-(Amino-KappaN)ethyl]phenyl-KappaC]chloro[dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine]-Palladium 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66146,CAS号为 1028206-56-5。 | |||
T76406 |
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)
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[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) 为高效的神经激肽 NK1 拮抗剂,能够有效抑制金蛋白 P 物质 (GPSP) 与 P 物质 (SP) 的活性。 | |||
T83808 |
Sp-Adenosine-5'-O-(1-thiotriphosphate) sodium
Sp-ATP-α-S |
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Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S) 是一种含硫核苷酸衍生物 ATP-α-S 的异构体,也是嘌呤P2Y1受体的激动剂。在表达P2Y1受体的HEK293细胞中增加钙离子的流动(对人类受体的EC50 = 9.4 nM)。Sp-ATP-α-S 抑制了ADP诱导的孤立人类血小板聚集(Ki = 4 μM)。它还能引起经卡巴胆碱预收缩的豚鼠十二指肠松弛(EC50 = 426 nM)。 | |||
T35485 |
6-Prenylindole
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6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity o... | |||
T79560 |
22-(4′-py)-JA
22-(4′-Pyridinecarbonyl) jorunnamycin A |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
22-(4′-py)-JA是久那霉素A的半合成衍生物,源自泰国蓝海绵(Xestospongia sp.)。该化合物显示出抗转移活性,能抑制AKT/mTOR/p70S6K信号通路,并阻断人脐静脉内皮细胞(HUVEC)中肿瘤细胞侵袭及管形成作用。它通过下调金属蛋白酶(MMP-2和MMP-9)、缺氧诱导因子1α(HIF-1α)和血管内皮生长因子(VEGF)来发挥作用。此外,22-(4′-py)-JA对非小细胞肺癌(NSCLC)显示出显著的抗癌效果。 | |||
T38103 |
Defensin HNP-3 (human) (trifluoroacetate salt)
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Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd... | |||
T37553 | (-)-Mycousnine | ||
(-)-Mycousnine is a microbial metabolite and derivative of usnic acid originally isolated fromM. nawaethat has antibacterial and antifungal activities.1,2It is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andS. aureus(MICs = 4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteriaE. coli,S. typhimurium, andK. pneumoniae(MICs = >128 g/ml for all).2(-)-Mycousnine is also active against the fungiT. mentagrophytes,T. rubrum, andC. albicans(MICs = 25, 25, and 100 μg/m... | |||
T36539 |
Nocardamine
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Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lo... | |||
T35742 |
IKD-8344
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IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vit... | |||
T35909 |
Penicinoline
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Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.1,2 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 μM for both).1 Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.2 It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 μg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 μg/ml). |1. Naveen, B., Ommi, N.B.,... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN7157 |
(+/-)-Longamide
Pyrrolo[1,2-a]pyrazin-1(2H)-one, 6,7-dibromo-3,4-dihydro-4-hydroxy-,6,7-dibromo-4-hydroxy-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one,6,7-dibromo-4-hydroxy-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazin-1-one |
Others | Others |
(+/-)-Longamide (6,7-dibromo-4-hydroxy-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazin-1-one) 是一种海洋来源的天然产物,存在于Agelas flabelliformis。 | |||
T35761 |
Carviolin
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Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2 1.Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory... | |||
T36438 |
Sporogen-AO 1
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Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(... | |||
T35752 |
Xanthoquinodin A1
Xanthoquinodin A1 |
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Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance... | |||
T36329 |
Terpendole I
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Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... |