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Search Results for " smn "

Targets Recommended: DNA/RNA Synthesis

16

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12935	SMN-C3 MV8T2MCK57	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SMN-C3 (MV8T2MCK57) 是口服有效的 SMN2 剪接调节剂。SMN-C3可用于脊椎肌肉萎缩 (SMA) 的研究。
T73475	SMN-C2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SMN-C2 是一种选择性的 SMN2 基因剪接调节剂，是risdiplam类似物，是调节前 mRNA 剪接的选择性 RNA 结合配体，通过结合 SMN2 pre-mRNA 来发挥作用。SMN-C2 具有研究脊髓性肌萎缩症 (SMA) 的潜力。
T4641	Branaplam LMI 070,NVS-SM1	Others; Potassium Channel; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Others
	Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂，对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期，也抑制 hERG，IC50为 6.3 μM。
T34664	SMN2-Stablizer-27 SMN2-Stablizer 27,SMN2 Stablizer-27
	SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).
T16902	SMND-309	Others	Others
	SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.
T16757	Risdiplam RO7034067,RG7916	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Risdiplam (RO7034067) 是一种中枢和外周分布的 SMN2 前 mRNA 剪接修饰剂，可增加运动神经元存活 (SMN) 蛋白水平。
T3336	Rg3039 PF-06687859	Others	Others
	Rg3039 (PF-06687859) 是一种具有口服活性、能够透过血脑屏障的DcpS 抑制剂，其IC50=0.069 nM。
T33764	NVS-SM2
	NVS-SM2 is an effective small molecule splicing enhancer of SMN2 with oral activity. NVS-SM2 showed increased exon 7 inclusion and upregulated SMN protein expression in SMA fibroblasts and SMN cells Δ7 5025 mouse myoblasts.
T35594	Cuspin-1
	The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Ra...
T26893	Branaplam mesylate (1562338-42-4 free base) LMI070,Branaplam mesylate,LMI 070,LMI-070
	Branaplam is a highly potent, selective and orally active SMN2 splicing modulator. Branaplam increases the amount of functional SMN protein produced by the SMN2 gene through modifying its splicing.
T78046	RG7800 tetrahydrochloride RO6885247 tetrahydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RG7800 hydrochloride为一可口服SMN2剪接调节剂，其对SMN2剪接及SMN蛋白的EC1.5x值分别为23 nM及87 nM。
T28067	ML372 ML 372,ML-372
	ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.
T62381	Branaplam hydrochloride
	Branaplam (LMI070; NVS-SM1) hydrochloride 是一种选择性的、口服具有活力的 SMN2 拼接调节剂，能够作用于 SMN (EC50: 20 nM)。Branaplam hydrochloride 能够抑制 hERG (IC50: 6.3 μM)。在严重的脊髓性肌萎缩症 (SMA) 小鼠模型中，Branaplam hydrochloride 能够增加全长 SMN 蛋白并提高其生存期。
T64288	RG7800 hydrochloride
	RG7800 hydrochloride 是一种口服具有活力的 SMN2 剪接调节剂，能够作用于 SMN2 剪接 (EC1.5x: 23 nM) 及 SMN 蛋白 (EC1.5x: 87 nM)。
T38656	Nusinersen
	Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.
T12718	RG7800 hydrochloride (1449598-06-4 free base) RO6885247 hydrochloride,RG7800 hydrochloride	Others	Others
	RG7800 hydrochloride is an orally active modulator of SMN2 splicing.

化合物

Cat.No: T12935

Synonym: MV8T2MCK57

Target: DNA/RNA Synthesis

Cat.No: T73475

Target: DNA/RNA Synthesis

Cat.No: T4641

Synonym: LMI 070,NVS-SM1

Target: Others, Potassium Channel, DNA/RNA Synthesis

SMN2-Stablizer-27

Cat.No: T34664

Synonym: SMN2-Stablizer 27,SMN2 Stablizer-27

Cat.No: T16902

Target: Others

Cat.No: T16757

Synonym: RO7034067,RG7916

Target: DNA/RNA Synthesis

Cat.No: T3336

Synonym: PF-06687859

Target: Others

Cat.No: T33764

Cat.No: T35594

Branaplam mesylate (1562338-42-4 free base)

Cat.No: T26893

Synonym: LMI070,Branaplam mesylate,LMI 070,LMI-070

RG7800 tetrahydrochloride

Cat.No: T78046

Synonym: RO6885247 tetrahydrochloride

Target: DNA/RNA Synthesis

Cat.No: T28067

Synonym: ML 372,ML-372

Branaplam hydrochloride

Cat.No: T62381

RG7800 hydrochloride

Cat.No: T64288

Cat.No: T38656

RG7800 hydrochloride (1449598-06-4 free base)

Cat.No: T12718

Synonym: RO6885247 hydrochloride,RG7800 hydrochloride

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03047	Stathmin 1 Protein, Human, Recombinant (His) SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR...	Human	E. coli
	Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom...
TMPH-02920	SMN1 Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293
	The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNR...
TMPH-03209	CLNS1A Protein, Rabbit, Recombinant (His & Myc) I(Cln),Chloride conductance regulatory protein ICln,Methylos...	Rabbit	E. coli
	Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the s...
TMPY-03456	SRFBP1 Protein, Human, Recombinant (His & GST) STRAP,BUD22,P49,serum response factor binding protein 1,p49/...	Human	Baculovirus-Insect Cells
	SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. SRFBP1 negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. SRF...
TMPH-02228	TRA2B Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
TMPH-02229	TRA2B Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
TMPH-01679	WDR77 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi p...

重组蛋白

Stathmin 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03047

Species: Human

Expression System: E. coli

SMN1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02920

Species: Mouse

Expression System: HEK293

CLNS1A Protein, Rabbit, Recombinant (His & Myc)

Cat.No: TMPH-03209

Species: Rabbit

Expression System: E. coli

SRFBP1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03456

Species: Human

Expression System: Baculovirus-Insect Cells

TRA2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02228

Species: Human

Expression System: Baculovirus

TRA2B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02229

Species: Human

Expression System: E. coli

WDR77 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01679

Species: Human

Expression System: E. coli

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