Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3986 |
SF2523
|
DNA-PK; Epigenetic Reader Domain; PI3K; mTOR | Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
SF2523 是一种选择性PI3K 抑制剂,抑制DNA-PK、PI3Kα、PI3Kγ、BRD4 和 mTOR,IC50分别为 9 nM、34 nM、158 nM、241 nM 和 280 nM。 | |||
T69531 |
SRX3212
|
||
SRX3212 is a Novel BRD4/PI3Kα inhibitor, displaying an IC50 of 3.7 nM toward BRD4BD1 and 32 nM toward BRD4BD2, and therefore was~65-fold more potent inhibitor of BRD4BD1 and~48-fold more potent inhibitor of BRD4BD2 than SF2523 (GLXC-10641), retaining its high inhibitory activity for PI3Kα (IC50: 22 nM). |