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Cat. No.	Product Name	Target	Signaling Pathways
T4031	S1p receptor agonist 1 S1p-receptor-agonist-1	S1P Receptor; LPL Receptor	GPCR/G Protein
	S1p receptor agonist 1 (S1p-receptor-agonist-1) 是有口服活性的S1P 受体激动剂，具有诱导 S1P1 内化的活性，EC50为9.83 nM。它有潜力用于关节炎和实验性自身免疫性脑炎)的相关研究。
T38826	Vibozilimod Vibozilimod,SCD-044	S1P Receptor	GPCR/G Protein
	Vibozilimod (SCD-044) 是S1P 受体-1 (S1PR1)激动剂。
T22102	ML-178 CYM50179	Others	Others
	ML-178 是一种二氯苯，是鞘氨醇-1-磷酸受体4（S1PR4）的强效选择性激动剂，EC50 为 46 nM，在25 μM 的浓度下对其他 S1P 受体没有影响。
T14924	Cenerimod ACT-334441	S1P Receptor	GPCR/G Protein
	Cenerimod (ACT-334441) 是一种具有口服活性、选择性和高效性的磷酸鞘氨醇 1 受体（S1P1）激动剂（EC50：1 nM）。Cenerimod 对多种 S1P 的亚型具有抑制作用，可用于研究鼠类实验性自身免疫性脑脊髓炎 (EAE)和鼠类硬皮病。
T14930	Ceralifimod ONO-4641	Others	Others
	Ceralifimod (ONO-4641) is a potent agonist for sphingosine 1-phosphate receptors 1 and 5 (EC50s: 27.3, 334 pM for human S1P receptor 1 and 5).
T15354	FTY720 (S)-Phosphate (S)-FTY720 phosphate,(S)-FTY720P	Others	Others
	FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury.
T62517	S1p receptor agonist 2
	S1p receptor agonist 2 (compound 1) 是一种 S1P5 受体的激动剂，选择性比 S1P1 和/或 S1P3 受体高。S1p receptor agonist 2 能够用于内源性 SIP 信号系统，以及减轻/预防中枢神经系统 (CNS) 疾病 (如神经退行性疾病) 的演技。
T78091	(S)-FTY720-phosphonate	LPL Receptor	GPCR/G Protein
	FTY720 (S)-Phosphate，作为S1P受体1 (S1PR1) 激动剂，可用于研究急性肺损伤等急性炎症。
T37548	azido-FTY720 azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...
T37187	D-erythro/L-threo Lysosphingomyelin (d18:1) D-erythro/L-threo Lysosphingomyelin (d18:1)
	Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O...