Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4663 |
QX77
|
Others; Autophagy | Autophagy; Others |
QX77 是一种分子伴侣介导的自噬激活剂,可上调 LAMP2A 的表达。它可抑制 ES 细胞的自我更新,促进分化。它诱导 Rab11 上调,挽救 Rab11 下调和转运缺陷。 | |||
T14919 |
CDKI-73
|
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
CDKI-73 是一种具有口服活性的 CDK9抑制剂,其对 CDK9、CDK1 和 CDK2 的Ki 值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。 | |||
T61663 |
SBI-581
|
||
SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice when administered via IP injection, demonstrating significant antitumor activity [1]. |