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Cat. No.	Product Name	Target	Signaling Pathways
T4687	Ro5-3335 CBFβ-Runx1 inhibitor II,Ro 5-3335	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ro5-3335 (CBFβ-Runx1 inhibitor II) 是苯二氮化合物，是RUNX1-CBFβ 相互作用抑制剂，可抑制 RUNX1/CBFB 依赖性反式激活，能作为核心结合因子 (CBF) 白血病抑制剂。
T61098	RUNX1/ETO tetramerization-IN-1
	RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1/ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully restores gene expression that has been down-regulated by RUNX1/ETO. Furthermore, RUNX1/ETO tetramerization-IN-1 demonstrates promising anti-leukemic activity by inhibiting the proliferation of SKNO-1 cells dependent on RUNX1/ETO and significantly reducing RUNX1/ETO-associated tumor g...
T28578	Ro24-7429 Ro 24-7429,Ro-24-7429,Ro 247429	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ro24-7429 是一种有效的口服活性 HIV-1 反式激活蛋白 Tat 拮抗剂和一种矮小相关转录因子 1 的抑制剂。Ro24-7429 具有抗 HIV、抗纤维化和抗炎作用。
T6753	AI-10-49	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	AI-10-49 是一种选择性的 CBFβ-SMMHC 与 RUNX1 结合抑制剂(IC50:260 nM)。
T22195	CBFβ Inhibitor 5-乙基-4-(4-甲氧基苯基)-1,3-噻唑-2-胺,5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) 是一种细胞渗透性 CBFβ 抑制剂，可抑制其与 Runx1 的结合。
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T24550	NSC-140873 GCPK
	NSC-140873 is the RUNX1-CBFβ interaction inhibitor.
T26580	AI-4-57 Hydrochloride AI457 HCl,AI-4-57 HCl,AI 4 57 HCl
	AI-4-57 Hydrochloride is a ligand to the CBFß. AI-4-57 Hydrochloride is a modest potency inhibitor of the binding of wildtype CBFß to the RUNX1 Runt domain.
T69678	WUN40378
	WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of Ro 24-7429. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).