Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74630 | RNA polymerase II-IN-1 | DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RNA polymerase II-IN-1(compound 19iv)是一款鹅膏毒素类化合物,能够抑制RNA聚合酶II(Pol II),其半抑制浓度IC50为36.66 nM。该化合物相较于α-Amanitin,对癌细胞展现出更高的细胞毒性,而对正常细胞的毒性较低。 | |||
T4356 |
POL1-IN-1
Compound 3A |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。 | |||
T79404 |
A09-003
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Apoptosis; BCL; CDK | Apoptosis; Cell Cycle/Checkpoint |
A09-003 是一种新型细胞周期蛋白依赖性激酶-9 CDK-9 抑制剂。A09-003 能够抑制多种白血病细胞系的增殖,抑制hi髓系细胞白血病序列-1蛋白增加。A09-003还能诱导细胞凋亡,降低 RNA 聚合酶 II 活性,降低 Mcl-1 表达。 | |||
T74631 | RNA polymerase II-IN-2 | ||
RNA polymerase II-IN-2 (compound 20iii)是高效的RNA polymerase II (Pol II)抑制剂,其Ki值为74.1 nM。该化合物对癌细胞展现出细胞毒性,其对CHO和HEK293细胞的毒性分别为α-amanitin的2倍和5倍。 | |||
T70988 |
Ibulocydine
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Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc... | |||
T36745 |
cDPCP
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cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad... |