Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5313 |
Sobetirome
IACS-010759,QRX-431 |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Sobetirome (IACS-010759) 是一种甲状腺激素受体 β (TRβ) 激动剂,能够选择性的结合到TRβ-1(EC50:0.16 μM)。 | |||
T27568 |
IACS-010759 hydrochloride
IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759 |
||
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I | |||
T5337 |
IACS-010759
IACS-10759,IACS 10759,IACS10759 |
Apoptosis; Others; Mitochondrial Metabolism | Apoptosis; Metabolism; Others |
IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡,有研究复发/难治性 AML 和实体瘤潜力。 |