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Search Results for " ptpn6 "

Targets Recommended: Apoptosis Phosphatase STAT

1

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8478	SC-43	Apoptosis; Phosphatase; STAT	Apoptosis; JAK/STAT signaling; Metabolism; Stem Cells
	SC-43 是一种具有口服活性的SHP-1 (PTPN6)激动剂。它是Sorafenib 的衍生物，可抑制STAT3的磷酸化并诱导细胞凋亡，具有抗纤维化和抗癌作用。

化合物

Cat.No: T8478

Target: Apoptosis, Phosphatase, STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00465	PTP1C Protein, Human, Recombinant (His) HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH-PTP1,...	Human	E. coli
	Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter...
TMPJ-00387	IL-4R alpha Protein, Mouse, Recombinant (hFc) Soluble IL-4R-alpha,Interleukin-4 receptor subunit alpha,Sol...	Mouse	HEK293 Cells
	Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic ...
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosine phosphatase, non...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...
TMPK-01066	BTLA Protein, Human, Recombinant (His & Avi) BTLA,BTLA1,FLJ16065,CD272,MGC129743	Human	HEK293 Cells
	B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. BTLA may interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. BTLA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight ...
TMPK-00530	BTLA Protein, Cynomolgus, Recombinant (His) MGC129743,CD272,BTLA,BTLA1,FLJ16065	Cynomolgus	HEK293 Cells
	B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. BTLA may interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. BTLA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15...
TMPK-00177	LAIR1 Protein, Human, Recombinant (His & Avi) CD305,LAIR1,LAIR-1,HLAIR1	Human	HEK293 Cells
	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium ...
TMPJ-00898	CD72 Protein, Human, Recombinant (Trx & His) Lyb-2,B-Cell Differentiation Antigen CD72,CD72	Human	E. coli
	B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells. CD72 is a ligand for CD5. CD72 associates with CD5, interacts with PTPN6/SHP-1 and plays a role in B-cell proliferation and differentiation. CD72 associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulat...
TMPJ-00193	TREML1 Protein, Human, Recombinant (hFc) TLT-1,Trem-Like Transcript 1 Protein,TLT1,Triggering Recepto...	Human	HEK293 Cells
	Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic...
TMPJ-00306	SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs...	Human	HEK293 Cells
	Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking ...
TMPJ-00305	SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His) Inhibitory Feceptor SHPS-1,MyD-1 Antig,Brain Ig-Like Molecul...	Cynomolgus	HEK293 Cells
	Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking ...
TMPH-03267	CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO) Clm1,Cd300lf,CD300 antigen-like family member F,CLM-1,CD300f...	Rat	E. coli
	Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ...
TMPJ-01182	SIRP alpha Protein, Mouse, Recombinant (MIgG2a) SIRP,CD172 Antigen-Like Family Member A,SIRPA,MFR,Signal-Reg...	Mouse	HEK293 Cells
	SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-l...

重组蛋白

PTP1C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00465

Species: Human

Expression System: E. coli

IL-4R alpha Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00387

Species: Mouse

Expression System: HEK293 Cells

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

BTLA Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01066

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00530

Species: Cynomolgus

Expression System: HEK293 Cells

LAIR1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00177

Species: Human

Expression System: HEK293 Cells

CD72 Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00898

Species: Human

Expression System: E. coli

TREML1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00193

Species: Human

Expression System: HEK293 Cells

SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00306

Species: Human

Expression System: HEK293 Cells

SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His)

Cat.No: TMPJ-00305

Species: Cynomolgus

Expression System: HEK293 Cells

CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03267

Species: Rat

Expression System: E. coli

SIRP alpha Protein, Mouse, Recombinant (MIgG2a)

Cat.No: TMPJ-01182

Species: Mouse

Expression System: HEK293 Cells

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