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Targets Recommended: p38 MAPK Serine Protease MAPK

1

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T16501 PF-3644022

p38 MAPK; Serine Protease; MAPK MAPK; Proteases/Proteasome
PF-3644022 是可口服的,具有 ATP 竞争性的MAPKAPK2 (MK2)选择性抑制剂,IC50为 5.2 nM,Ki 为 3 nM。它有效抑制 TNFα 的产生并具有抗炎作用,还抑制 MK3 和 p38 调节/激活激酶,IC50分别为 53 和 5.0 nM。

化合物

PF-3644022
Cat.No: T16501
Synonym:
Target: p38 MAPK, Serine Protease, MAPK
Cat. No. Product Name Species Expression System
TMPY-04425 PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)

PRAK,MAPKAP-K5,MK-5,mitogen-activated protein kinas...

Human Baculovirus Insect Cells
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulator...
TMPK-00696 PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)

MAPKAPK5,MK5,MAPKAP-K5,MK-5,MAPKAPK-5

Human Baculovirus Insect Cells
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-activated protein kinase activated protein kinase 5 [MAPKAPK5]) functions downstream of p38alpha and p38beta in mediating the signaling of the p38 pathway.

重组蛋白

PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04425
Species: Human
Expression System: Baculovirus Insect Cells
PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)
Cat.No: TMPK-00696
Species: Human
Expression System: Baculovirus Insect Cells
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