首页工具

登录

搜索结果

Search Results for " pge1 "

19

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T29908	Alprostadil ethyl ester Prostaglandin E1 ethyl ester,PGE1 ethyl ester
	Alprostadil ethyl ester is a biochemical used in the treatment of scleroderma.
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T15757	Limaprost 17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206	PGE Synthase	Immunology/Inflammation
	Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物，也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能，可用于疼痛的缓解，以及用于研究缺血性症状。
T36775	13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1
	13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hyb...
T34550	SC 31391 SC31391,SC-31391
	SC 31391 is a PGE1 analog.
T36726	6-keto Prostaglandin E1 6-keto Prostaglandin E1
	6-keto Prostaglandin E1 是 PGE1 的生物活性衍生物，在抗血小板聚集和解聚作用方面发挥作用。
T36147	13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1
	13,14-dihydro-15-keto Prostaglandin E1 可抑制 ADP 诱导的人离体富血小板血浆中的血小板聚集（IC50=14.8 μg/mL），也是 PGE1 代谢物。
T36214	16,16-dimethyl Prostaglandin E1 16,16-dimethyl Prostaglandin E1
	16,16-dimethyl Prostaglandin E1 是 PGE1 (T1626) 类似物，可诱导支气管收缩和血管平滑肌收缩，并抑制吲哚美辛诱导的细胞伸长。
T36154	15(S)-15-methyl Prostaglandin E2 15(S)-15-methyl Prostaglandin E2
	15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.
T73346	SC 34301 Enisoprost
	SC 34301 (Enisoprost)为有效的口服活性PGE1类似物，显著降低细菌移位并提升烧伤小鼠存活率。
T37773	tetranor-PGEM tetranor-Prostaglandin E Metabolite,tetranor-PGEM
	tetranor-PGEM is the major urinary metabolite of PGE1 and PGE2, and is used as a marker of PGE2 biosynthesis.[1],[2] About 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 μg of tetranor-PGEM over a 24-hour period.[1]
T36209	15-keto Prostaglandin A1 15-keto Prostaglandin A1
	Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 μM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.
T36157	8-iso Prostaglandin A1 8-iso Prostaglandin A1
	8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.
T70865	BMY-42393
	BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM). BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM). Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. B...
T37233	(±)14(15)-EpEDE
	8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. It can be metabolized by the cyclooxygenase pathway to produce 1-series prostaglandins (PGs) (e.g., PGE1). (±)14(15)-EpEDE is an EpEDE acid formed from 8,11,14-eicosatrienoic acid. This monoepoxide can be generated from the PUFA, in vitro, by the action of a strong oxidizing agent. Alternatively, this compound may be pro...
T36167	8-iso-15-keto Prostaglandin F2β 8-iso-15-keto Prostaglandin F2β
	8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8...
T83807	Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium Rp-ATP-α-S
	Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。
T62532	MRS2395
	MRS2395 是一种二戊酰衍生物，是一种 P2Y12 受体的有效拮抗剂。MRS2395 抑制 ADP 诱导的血小板活化 (Ki: 3.6 μM)。MRS2395 在 PGE1 存在下，对大鼠血小板中 ADP 诱导的 cAMP 具有抑制作用 (IC50: 7 μM)。MRS2395 增强血小板致密颗粒释放以响应 TRAP-6。
T37441	KMN-80
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...

化合物

Alprostadil ethyl ester

Cat.No: T29908

Synonym: Prostaglandin E1 ethyl ester,PGE1 ethyl ester

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Cat.No: T15757

Synonym: 17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206

Target: PGE Synthase

13,14-dihydro Prostaglandin E1

Cat.No: T36775

Synonym: 13,14-dihydro Prostaglandin E1

Cat.No: T34550

Synonym: SC31391,SC-31391

6-keto Prostaglandin E1

Cat.No: T36726

Synonym: 6-keto Prostaglandin E1

13,14-dihydro-15-keto Prostaglandin E1

Cat.No: T36147

Synonym: 13,14-dihydro-15-keto Prostaglandin E1

16,16-dimethyl Prostaglandin E1

Cat.No: T36214

Synonym: 16,16-dimethyl Prostaglandin E1

15(S)-15-methyl Prostaglandin E2

Cat.No: T36154

Synonym: 15(S)-15-methyl Prostaglandin E2

Cat.No: T73346

Synonym: Enisoprost

tetranor-PGEM

Cat.No: T37773

Synonym: tetranor-Prostaglandin E Metabolite,tetranor-PGEM

15-keto Prostaglandin A1

Cat.No: T36209

Synonym: 15-keto Prostaglandin A1

8-iso Prostaglandin A1

Cat.No: T36157

Synonym: 8-iso Prostaglandin A1

Cat.No: T70865

(±)14(15)-EpEDE

Cat.No: T37233

8-iso-15-keto Prostaglandin F2β

Cat.No: T36167

Synonym: 8-iso-15-keto Prostaglandin F2β

Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83807

Synonym: Rp-ATP-α-S

Cat.No: T62532

Cat.No: T37441

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
TQ0262	Dihomo-γ-linolenic acid Diroleuton,顺式-8，11，14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989	Others	Others
	Ro 12-1989 can be converted into prostaglandin E1 (PGE1). Ro 12-1989 competes with arachidonic acid for COX and lipoxygenase, inhibiting the production of arachidonic acid's eicosanoids.

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

Dihomo-γ-linolenic acid

Cat.No: TQ0262

Synonym: Diroleuton,顺式-8，11，14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼