Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12412 |
PDK4-IN-1
|
Others | Others |
PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM). | |||
T12412L |
PDK4-IN-1 hydrochloride
|
Apoptosis; PDK | Apoptosis; PI3K/Akt/mTOR signaling |
PDK4-IN-1 hydrochloride 是一种蒽醌衍生物,对丙酮酸脱氢酶激酶 4有抑制作用,IC50为 84 nM,具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏,抗糖尿病和抗癌作用。 | |||
T79723 |
PDK-IN-2
|
||
PDK-IN-2(Compound 1F)是一种具有IC50为68 nM的PDK抑制剂。该化合物能够抑制PDK1和PDK4在细胞内的表达,增强线粒体生物能并降低糖酵解表型,同时诱导细胞走向线粒体途径的apoptosis。此外,PDK-IN-2在4T1同基因小鼠模型中能够有效抑制肿瘤生长。 |