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Search Results for " pdi "

15

抑制剂 & 化合物

4

天然产物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T24608	PDI-IN-P1 PDI inhibitor P1,PDIINP1,PDI-inhibitor-P1
	PDI-IN-P1 is an inhibitor of protein disulfide isomerase.
T8640	G6PDi-1	Dehydrogenase	Metabolism
	G6PDi-1 是一种有效的 G6PD 抑制剂。它消耗 NADPH 并减少炎性细胞因子的产生。
T25821	ML359 ML-359,ML 359	Others	Others
	ML359 是选择性可逆的蛋白质二硫键异构酶有效抑制剂(IC50:250 nM)。它对体内血栓形成具有抑制作用。
T6800	CCF642 AC1LYELL	Others	Others
	CCF642 (AC1LYELL) 是蛋白质二硫键异构酶抑制剂(IC50:2.9 μM)。它在多发性骨髓瘤细胞中引起急性内质网应激，并伴随凋亡诱导的钙释放，表现出广泛的抗多发性骨髓瘤作用。
T30473	Bis-hema ipdi
	Bis-hema ipdi is a bioactive chemical.
T5453	3-Methyltoxoflavin 3-methyl toxoflavin	Others	Others
	3-Methyltoxoflavin (3-methyl toxoflavin) 是蛋白质二硫键异构酶抑制剂(IC50:170 nM)。
T5534	LOC14	Others	Others
	LOC14 是一种蛋白质二硫键异构酶抑制剂 (EC50=500 nM;Kd=62 nM)。它抑制 PDIA3 活性，降低肺上皮细胞中 HA 的分子内二硫键和随后的寡聚化。它在小鼠肝微粒体和血浆中表现出高稳定性，低内在微粒体清除率和低血浆蛋白结合。
T11141	E64FC26	Others	Others
	E64FC26 是一种有效的蛋白质二硫键异构酶 (PDI) 家族泛抑制剂，具有抗肿瘤活性，抑制 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6，可用于研究多发性骨髓瘤和胰腺癌。
T41277	PACMA 31	Others	Others
	PACMA 31 是一种不可逆的共价蛋白二硫键异构酶 (PDI) 抑制剂，IC50 为 10 μM。 PACMA 31 显着抑制卵巢肿瘤生长并表现出肿瘤靶向能力。
T69718	Bacitracin F
	Bacitracin F is a major Bacitracin analog -- a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI).
T19505	PBDB-T	Others	Others
	PBDB-T serves as a wide-bandgap polymer donor within polymer solar cells that utilize Perylene Diimide (PDI) as the base.
T35608	16F16
	16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal ...
T69700	BAP2
	BAP2 is a novel inhibitor of protein disulfide isomerase (PDI).
T71589	AS15
	AS15 is a novel covalent nanomolar inhibitor of protein disulfide isomerase (PDI).
T39812	(E/Z)-E64FC26 (E/Z)-E64FC26
	(E/Z)-E64FC26 is a mixture complex comprising E-E64FC26 and Z-E64FC26. E-E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50 values of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Furthermore, E64FC26 demonstrates anti-myeloma activity.

化合物

Cat.No: T24608

Synonym: PDI inhibitor P1,PDIINP1,PDI-inhibitor-P1

Cat.No: T8640

Target: Dehydrogenase

Cat.No: T25821

Synonym: ML-359,ML 359

Target: Others

Cat.No: T6800

Synonym: AC1LYELL

Target: Others

Cat.No: T30473

3-Methyltoxoflavin

Cat.No: T5453

Synonym: 3-methyl toxoflavin

Target: Others

Cat.No: T5534

Target: Others

Cat.No: T11141

Target: Others

Cat.No: T41277

Target: Others

Cat.No: T69718

Cat.No: T19505

Target: Others

Cat.No: T35608

Cat.No: T69700

Cat.No: T71589

Cat.No: T39812

Synonym: (E/Z)-E64FC26

Cat. No.	Product Name	Target	Signaling Pathways
T4S1057	Tripdiolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
T3752	4-Hydroxybenzyl alcohol 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物，具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长，有神经保护作用。
T82003	Juniferdin
	Juniferdin是一种抑制Protein disulfide isomerase (PDI)，IC50为3.5 μM，旨在阻断HIV传播的化合物。此外，Juniferdin展现出细胞毒性并能抑制血小板聚集。
T74207	Ribostamycin
	Ribostamycin (Vistamycin) 是一种广谱氨基糖苷类抗生素 (antibiotic)。Ribostamycin 对革兰氏阴性和革兰氏阳性细菌感染有效。Ribostamycin 还抑制PDI 的伴侣活性。

天然产物

Cat.No: T4S1057

Target: IL Receptor, TNF

4-Hydroxybenzyl alcohol

Cat.No: T3752

Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Target: Apoptosis, Endogenous Metabolite

Cat.No: T82003

Cat.No: T74207

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01012	P4HB Protein, Human, Recombinant (His) DSI,prolyl 4-hydroxylase, β polypeptide,PDIA1,P...	Human	HEK293
	Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identifi...
TMPY-00021	PADI4 Protein, Human, Recombinant (His) PADI5,PAD4,PDI4,peptidyl arginine deiminase, type I...	Human	Baculovirus-Insect Cells
	Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres...
TMPH-03318	IL-11 Protein, Rat, Recombinant (His & PDI)	Rat	Yeast
	IL-11 Protein, Rat, Recombinant (His & PDI) is expressed in Yeast.
TMPY-01795	P4HB Protein, Mouse, Recombinant (His) ERp59,Pdia1,prolyl 4-hydroxylase, beta polypeptide,...	Mouse	HEK293 Cells
	P4HB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.2 kDa and the accession number is P09103.
TMPK-00502	PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated PDI5,HL-60,PAD,PADI5,Protein-arginine deiminase typ...	Cynomolgus	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.
TMPK-01238	PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated PDI5,Protein-arginine deiminase type-4,HL-60,PAD4,H...	Human	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.
TMPK-00501	PADI4 Protein, Cynomolgus, Recombinant (His) Protein-arginine deiminase type-4,HL60 PAD,PAD,PDI5...	Cynomolgus	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.
TMPJ-00532	PADI4 Protein, Human, Recombinant (E. coli, His) PDI5,PADI4,Protein-arginine Deiminase type IV,HL-60...	Human	E. coli
	Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune fe...
TMPJ-01124	PDIA6 Protein, Human, Recombinant (His) Thioredoxin Domain-Containing Protein 7,P5,ERP5,TXNDC7,Prote...	Human	Human Cells
	Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA...
TMPJ-00935	PDIA3 Protein, Human, Recombinant (His) PDIA3 protein,Disulfide isomerase ER-60,ER protein ...	Human	Human Cells
	PDIA3 protein is also known as Protein disulfide-isomerase A3. It is a protein that in humans is encoded by the PDIA3 gene.PDIA3 is an enzyme that belongs to the endoplasmic reticulum and interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. PDIA3 interacts with thiazide-sensitive sodium-chloride cotransporter in the kidney and is induced by glucose deprivation. PDIA3 is part of the major histocompatibility complex (MHC) class I peptid...
TMPJ-00461	PDIA5 Protein, Human, Recombinant (His) Protein disulfide isomerase-related protein,PDIR,	Human	Human Cells
	Protein disulfide-isomerase A5 is a 519 amino acids protein that belongs to the protein disulfide isomerase family.It contains 3 thioredoxin domains.It can catalyze the rearrangement of -S-S- bonds in proteins.
TMPJ-01225	PDILT Protein, Human, Recombinant (His) PDILT,Protein Disulfide-Isomerase-Like Protein of t...	Human	Human Cells
	Protein Disulfide-Isomerase-Like Protein of the Testis (PDILT) is a protein that belongs to the protein disulfide isomerase family. Human PDILT is synthesized as a 584 amino acid precursor that contains an 20 amino acid signal sequence and a 564 amino acid mature chain. PDILT contains 1 thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity. PDILT is an enzyme in the endoplasmic reticulum in eukary...
TMPH-02851	PDIA2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
TMPJ-01274	ERO1L Protein, Human, Recombinant (His) ERO1-L-Alpha,ERO1-L-α,Oxidoreductin-1-L-α,Endoplasmic Oxidor...	Human	Human Cells
	ERO1-Like Protein α (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. ERO1L acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It associates with ERP44, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. It...
TMPY-02890	ERP27 Protein, Human, Recombinant (mFc) endoplasmic reticulum protein 27,C12orf46,PDIA8	Human	HEK293
	ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartmen...
TMPY-04205	AGR3 Protein, Human, Recombinant (mFc) hAG-3,AG3,HAG3,anterior gradient 3,PDIA18,BCMP11,AG...	Human	HEK293
	Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been...
TMPJ-00056	AG-2 Protein, Human, Recombinant (His) HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Homolog,AGR2...	Human	Human Cells
	Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E...

重组蛋白

P4HB Protein, Human, Recombinant (His)

Cat.No: TMPY-01012

Species: Human

Expression System: HEK293

PADI4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00021

Species: Human

Expression System: Baculovirus-Insect Cells

IL-11 Protein, Rat, Recombinant (His & PDI)

Cat.No: TMPH-03318

Species: Rat

Expression System: Yeast

P4HB Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01795

Species: Mouse

Expression System: HEK293 Cells

PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Cat.No: TMPK-00502

Species: Cynomolgus

Expression System: E. coli

PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-01238

Species: Human

Expression System: E. coli

PADI4 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00501

Species: Cynomolgus

Expression System: E. coli

PADI4 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00532

Species: Human

Expression System: E. coli

PDIA6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01124

Species: Human

Expression System: Human Cells

PDIA3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00935

Species: Human

Expression System: Human Cells

PDIA5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00461

Species: Human

Expression System: Human Cells

PDILT Protein, Human, Recombinant (His)

Cat.No: TMPJ-01225

Species: Human

Expression System: Human Cells

PDIA2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02851

Species: Mouse

Expression System: E. coli

ERO1L Protein, Human, Recombinant (His)

Cat.No: TMPJ-01274

Species: Human

Expression System: Human Cells

ERP27 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-02890

Species: Human

Expression System: HEK293

AGR3 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04205

Species: Human

Expression System: HEK293

AG-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00056

Species: Human

Expression System: Human Cells

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