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Search Results for " pcsk-9 "

8

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39685	PCSK9 degrader 1
	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T13813	PCSK9 ligand 1	Others	Others
	PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).
T39528	PCSK9-IN-2 PCSK9-IN-2
	PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
T76974	Tafolecimab
	Tafolecimab (IBI-306) 是一种人源 lgG2 单克隆抗体，可特异性结合 PCSK-9并通过抑制 PCSK-9 介导的低密度脂蛋白受体的内吞作用降低 LDL-C 水平，进而增强对 LDL-C 的清除，导致 LDL-C 水平降低。Tafolecimab 可用于高胆固醇血症的研究。
T39122	Inclisiran ALN-PCSsc
	Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (CVD).
T74249	AS(3n-2)-Inclisiran
	AS(3n-2)-Inclisiran 是 Inclisiran 的反义链，其在 2 bp 的间隔后有3n 个随机位点。Inclisiran 是一种双链小干扰 RNA (siRNA) 分子，可抑制PCSK-9的转录。
T74248	AS-Inclisiran
	AS-Inclisiran为Inclisiran的反义链。Inclisiran（ALN-PCSsc）为双链小干扰RNA（siRNA）分子，目的在于抑制PCSK-9的转录，适用于高脂血症及心血管疾病（CVD）的研究。
T74876	GalNAc unconjugated/naked Inclisiran
	GalNAc unconjugated/naked Inclisiran 是一种未偶联GalNAc的双链小干扰RNA (siRNA) 分子，具有抑制PCSK-9转录功能。该化合物主要应用于高脂血症及心血管疾病(CVD)的研究领域。

化合物

PCSK9 degrader 1

Cat.No: T39685

PCSK9 ligand 1

Cat.No: T13813

Target: Others

Cat.No: T39528

Synonym: PCSK9-IN-2

Cat.No: T76974

Cat.No: T39122

Synonym: ALN-PCSsc

AS(3n-2)-Inclisiran

Cat.No: T74249

Cat.No: T74248

GalNAc unconjugated/naked Inclisiran

Cat.No: T74876

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00483	PCSK9 Protein, Cynomolgus, Recombinant (His) PCSK9	Cynomolgus	HEK293 Cells
	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His) Proprotein Convertase Subtilisin/Kexin Type 9,P...	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPJ-00368	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PC9,NAR...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPJ-00369	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PCSK	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7.
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698	VEGF121b Protein, Human, Recombinant MVCD1,VEGF,VPF,vascular endothelial growth factor A	Human	HEK293 Cells
	VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005	YAP1 Protein, Human, Recombinant (Isoform 9, His) YAP1-2delta	Human	P. pastoris (Yeast)
	YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825	VEGF121 Protein, Human, Recombinant (His & Avi) VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826	VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated NRCAML,neurofascin,NF	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

PCSK9 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00483

Species: Cynomolgus

Expression System: HEK293 Cells

PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Cat.No: TMPJ-00443

Species: Macaca nemestrina

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00368

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Cat.No: TMPJ-00369

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

VEGF121b Protein, Human, Recombinant

Cat.No: TMPY-03698

Species: Human

Expression System: HEK293 Cells

YAP1 Protein, Human, Recombinant (Isoform 9, His)

Cat.No: TMPH-00005

Species: Human

Expression System: P. pastoris (Yeast)

VEGF121 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00825

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00826

Species: Human

Expression System: HEK293 Cells

Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05268

Species: Human

Expression System: HEK293 Cells

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