Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2503 |
PAC-1
Procaspase activating compound 1 |
Apoptosis; Caspase; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome |
PAC-1 (Procaspase activating compound 1) 是一种 procaspase-3激活剂,诱导癌细胞凋亡,EC50为 2.08 μM,可用于研究淋巴瘤、黑色素瘤、实体瘤、乳腺癌和胸癌等治疗的试验。 | |||
T18603 | PROTAC BRD4 degrader for PAC-1 | Others | Others |
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1. | |||
T50096 |
1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride
|
Others | Others |
1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride,又称PAC,是一种环胺,通常用作不对称合成中的手性助剂,包括Diels-Alder 反应、羟醛反应和Michael 加成。 | |||
T2238 |
Cariporide
卡立泊来德,HOE-642 |
Sodium Channel | Membrane transporter/Ion channel |
Cariporide (HOE-642) 是一种选择性的Na+/H+交换抑制剂。 | |||
T18607 |
PROTAC ER Degrader-3
|
Others | Others |
PROTAC ER Degrader-3, an intermediate for the synthesis of PAC, specifically compound LP2. PAC serves as the linker for ADCs and PROTACs that are conjugated to an antibody. Notably, when PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) compared to PROTAC alone [1]. | |||
T18606 | PROTAC ER Degrader-2 | Others | Others |
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, exhibits a greater capability to degrade estrogen receptor-alpha (ERα) compared to PROTAC (without the presence of an antibody)[1]. | |||
T37139 |
5'-O-DMT-PAC-dA
|
||
5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1]. [1]. Schulhof JC, et, al. The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups. Nucleic Acids Res. 1987 Jan 26;15(2):397-416. |