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Cat. No. | Product Name | Target | Signaling Pathways |
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T11637 |
Iloperidone metabolite Hydroxy Iloperidone
P88,伊潘立酮代谢物,Hydroxy Iloperidone |
Others | Others |
Iloperidone metabolite Hydroxy Iloperidone is an atypical antipsychotic. It is a metabolite of Iloperidone. | |||
T14573 |
Bimosiamose disodium
TBC-1269Z |
Integrin | Cytoskeletal Signaling |
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. | |||
T14574 |
Bimosiamose
TBC-1269 |
Integrin | Cytoskeletal Signaling |
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively. | |||
T37730 |
Saccharocarcin A
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Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml. | |||
T79633 |
Antileishmanial agent-22
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Parasite | Microbiology/Virology |
Antileishmanial agent-22 (compound 15b)是一种抗寄生虫和抗菌化合物,展示了对抗利什曼病、疟疾和结核病的活性。该化合物通过抗叶酸途径抑制利什曼原虫(IC50=0.408 μM)。在100 μM浓度时,Antileishmanial agent-22对叶酸和亚叶酸的抑制率分别达到88%和94%。在体内,以48.4 μM/kg/day剂量对伯氏疟原虫展示96.67%的抑制效果;在体外,其IC50值为0.038 μM。Antileishmanial agent-22还能抑制结核分枝杆菌,MIC值为28.44 μM。 | |||
T35829 | CC-90005 | ||
CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression[1]. CC-90005 shows the exquisite selectivity of CC-90005, with IC50s for all other family members of >3 μM[1].CC-90005 is a moderate inhibitor of both CYP2C9 (IC50=8 μM) and CYP2C19 (IC50=5.9 μM) in human liver microsomes[1].CC-90005 inhibits IL-2 expression in LRS... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN5438 |
Lariciresinol p-coumarate
(+)-Lariciresinol 9'-p-coumarate |
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Lariciresinol p-coumarate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5438,CAS号为 864452-88-0。 | |||
T36179 |
Aspulvinone O
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Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu... |