Cat. No. | Product Name | Target | Signaling Pathways |
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T40925 |
Peripheral Myelin Protein P2 (53-78), bovine
Peripheral Myelin Protein P2 (53-78), bovine |
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Bovine Peripheral Myelin Protein P2 (53-78) is a derivative composed of amino acid residues 53 to 78 from the peripheral myelin P2 protein of bovine origin. It acts as a T cell epitope and is used to induce experimental autoimmune neuritis (EAN) in Lewis rats. | |||
T41068 |
P53R3
|
p53 | Apoptosis |
P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合,包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用,其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5(DR5)的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。 | |||
T72026 |
p53-MDM2-IN-1
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Mdm2; p53 | Apoptosis |
p53-MDM2-IN-1 (Example 30) 是一种 p53-MDM2/X 蛋白相互作用的抑制剂,Ki 值为 23.35 µM。p53-MDM2-IN-1 能用于抗肿瘤研究。 | |||
T67698 |
p53-Mdm2 inhibitor 4
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Mdm2; p53 | Apoptosis |
p53-Mdm2 inhibitor 4 抑制 p53-MDM2 蛋白质-蛋白质相互作用。 | |||
T72771 |
p53 Activator 7
|
Apoptosis | Apoptosis |
p53 Activator 7 是一种高效性和细胞渗透性的 p53 突变 Y220C (MDM-2/p53) 激活剂,可诱导细胞凋亡 。 | |||
T34830 |
Tetrofosmin
P 53,P53 |
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Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. | |||
TP2281 |
p53 tumor suppressor fragment
|
Others | Others |
p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where i | |||
T80233 |
p53 CBS
p53 Consensus binding sequence |
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p53 CBS(p53共有DNA结合位点)是一种具备生物活性的肽类化合物。 | |||
T61369 |
p53 Activator 2
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p53 Activator 2 (compound 10ah) 插入DNA,导致显著的DNA双链断裂。该化合物通过增加p53、p-p53、CDK4、p21的表达,使细胞周期在G2/M期停滞,诱导细胞凋亡,并显著降低抗凋亡蛋白Bcl-2、Bcl-xL和cyclin B1的水平。此外,p53 Activator 2表现出对MGC-803细胞的抗增殖效果,其IC50为1.73 μM,且在MGC-803异种移植肿瘤模型中展示出有效的抗癌活性。 | |||
T72770 | p53 Activator 5 | ||
p53 Activator 5 是一种有效的 p53激活剂,SC150 值 <0.05 mM。p53 Activator 5 可以结合突变体 p53 并恢复 p53 突变体结合 DNA 的能力。p53 Activator 5 具有抗肿瘤活性。 | |||
T72769 |
p53 Activator 3
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p53 Activator 3,一种有效的p53激活剂,其SC150值<0.05 mM。该化合物能结合p53突变体并恢复其与DNA结合的功能,显示出抗肿瘤活性。 | |||
TP1794 |
p53 (17-26)
p53 17-26 |
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This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. | |||
TP2299 |
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
|
Others | Others |
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent tra | |||
T64079 | Mutant p53 modulator-1 | ||
Mutant p53 modulator-1 是一种突变型 p53 调节剂。Mutant p53 modulator-1 能够阻碍含有 p53 突变的癌症的进展。 | |||
T72877 | p53-HDM2-IN-1 | ||
p53-HDM2-IN-1 是一种有效的 p53-HDM2蛋白-蛋白相互作用抑制剂,IC50值为 0.103 μM。p53-HDM2-IN-1 可用于癌症研究。 | |||
T72832 |
MDM2-p53-IN-16
|
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MDM2-p53-IN-16 是MDM2-p53复合体抑制剂,其IC50值针对人MDM2-p532复合体为4.3 nM。该化合物能够重新激活p53,进而诱导多形性成胶质细胞瘤(GBM)细胞的凋亡和细胞周期阻滞,适用于癌症研究。 | |||
T63373 |
S100A2-p53-IN-1
|
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S100A2-p53-IN-1(化合物 51)是一款针对S100A2-p53相互作用的抑制剂,专用于阻断S100A2与p53的相互作用。作为一种与Ca2+结合并参与细胞信号传递的蛋白,S100A2在胰腺癌中表达上调。S100A2-p53-IN-1特别针对MiaPaCa-2胰腺癌细胞系,显示出良好的生长抑制效果(GI50为1.2-3.4 μM)。 | |||
T12350 |
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
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Others | Others |
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins. | |||
T74935 | MDM2/4-p53-IN-2 | ||
MDM2/4-p53-IN-2 (2q) 是一种有效的双重 MDM2/ MDM4抑制剂和 p53激活剂,作用于 MDM2-p53 和 MDM4-p53 复合物的 IC50值分别是 70.7 nM 和 81.4 nM。MDM2/4-p53-IN-2 可以调控细胞周期,诱导细胞凋亡(apoptosis),具有抗癌活性。 | |||
T74936 | MDM2/4-p53-IN-3 | ||
MDM2/4-p53-IN-3,一种针对MDM2/4-p53蛋白-蛋白相互作用(PPI)的抑制剂,IC50s分别为18.5 nM(MDM2-p53)与14.8 nM(MDM4-p53)。该化合物主要应用于癌症研究领域,特别是结肠癌的研究。 | |||
T63438 | rel-MDM2/4-p53-IN-3 | ||
rel-MDM2/4-p53-IN-3 是 MDM2/4-p53 蛋白质-蛋白质相互作用 (PPI) 抑制剂,能够作用于MDM2-p53、MDM4-p53,其IC50值分别为18.5 nM、14.8 nM。rel-MDM2/4-p53-IN-3 能够用于研究癌症,如结肠癌。 | |||
T63748 | rel-MDM2/4-p53-IN-2 | ||
rel-MDM2/4-p53-IN-2 (2q) 是有效的双重 MDM2/MDM4 抑制剂和 p53 激活剂,能够作用于 MDM2-p53 复合物 (IC50: 70.7 nM) 和 MDM4-p53 复合物 (IC50: 81.4 nM)。rel-MDM2/4-p53-IN-2 能够调控细胞周期,诱导细胞凋亡(apoptosis),表现出抗癌效果。 | |||
T12351 |
p53 and MDM2 proteins-interaction-inhibitor (racemic)
p53-and-mdm2-proteins-interaction-inhibitor-racemic |
Others | Others |
p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins. | |||
TP1899L1 |
Hemokinin 1 (human) acetate(491851-53-7 free base)
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Hemokinin 1 (human) acetate(491851-53-7 free base) 是一种内源性 P 物质同系物,是速激肽 NK1 受体的选择性激动剂(NK1、NK3 和 NK2 受体的 IC50 值分别为 1.8、370 和 480 nM)。在体外对 B 细胞具有增殖和抗凋亡作用,在体内具有抗高血压作用。 | |||
T36021 |
Flumequine-13C3
Flumequine-13C3 |
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Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl... |