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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2621 |
Rostafuroxin
PST 2238 |
ATPase; RSV | Membrane transporter/Ion channel; Microbiology/Virology |
Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物,是一种口服有效的 Na+,K+-ATPase 抑制剂,具有抗高血压和抗 RSV 活性,用于研究治疗原发性高血压的试验。 | |||
T8965 |
VK-II-86
|
Others | Others |
VK-II-86 是一种非β-阻断卡维地洛类似物。它可以防止哇巴因诱导的心脏毒性。 | |||
T81275 |
Riboxin
IDP |
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Riboxin (IDP) 是一种抗缺氧及抗高血压活性的口服有效嘌呤衍生物次黄苷。该化合物对心律失常也具有治疗作用,能够干预Ouabain诱导的猫、兔子、小鼠的心脏节律障碍模型。此外,Riboxin还能保护动物不受γ辐射的损害。 | |||
T37766 |
Transdermal Peptide (TD 1 (peptide))
|
||
Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules. Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts with the C-terminus of ATP1B1 in yeast and mammalian cells. The interaction affects the expression and localization of ATP1B1 and epidermal structure, but can be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain. Inhibition of Transdermal Peptide binding t... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3432 |
Cinobufagin
华蟾蜍精,华蟾酥毒基,Cinobufagine |
Apoptosis; ATPase; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。 | |||
T5645 |
Nerol
Cis-Geraniol,橙花醇,Neryl alcohol |
Apoptosis; Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite; Antifungal | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Nerol (Neryl alcohol) 是橙花油的一种单萜, 它通过增强 Ca2+和ROS 来触发线粒体功能障碍并诱导凋亡,具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。 |