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Search Results for " ox2r "

Targets Recommended: OX Receptor

13

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3177	Orexin 2 Receptor Agonist OX2R	OX Receptor	GPCR/G Protein; Neuroscience
	Orexin 2 Receptor Agonist (OX2R) 是一种选择性有效的OX2R 激动剂， EC50为23 nM。
T62855	OX2R-IN-1
	OX2R-IN-1 是一种 OX2R 拮抗剂 (一种潜在的 OX2R 结合剂)，表现出低细胞毒性 (IC50: 484 μM)。OX2R-IN-1 具有血脑屏障通透性，药物半衰期短。
T3722	MK-1064 Urokinase inhibitor 1,MK 1064	OX Receptor	GPCR/G Protein; Neuroscience
	MK-1064 (Urokinase inhibitor 1) 是一种选择性食欲素 2 (2-SORA)受体拮抗剂，可用于失眠患者的研究。
T39229	YNT-185	OX Receptor	GPCR/G Protein; Neuroscience
	YNT-185 是一种非肽类、选择性的俄睾丸激素2型受体(OX2R)激动剂，对 OX2 R和 OX1R 的 EC50 值分别为 0.028 μM 和 2.75 μM。此外，YNT-185 在小鼠模型中有效缓解了嗜睡症-猝倒症的症状。
T12877L	Seltorexant JNJ-42847922	OX Receptor	GPCR/G Protein; Neuroscience
	Seltorexant (JNJ-42847922) 是一种可口服，高亲和性以及选择性的 orexin-2 受体(OX2R)拮抗剂，对人和大鼠中的 OX2R 的pKi 值分别为 8.0 和 8.1。它穿过血脑屏障，迅速占据大鼠大脑中的 OX2R 结合位点。
T5503	IPSU	OX Receptor	GPCR/G Protein; Neuroscience
	IPSU 是可口服和脑渗透性的选择性OX2R 拮抗剂，pKi 值为7.85。
T4965	TCS-OX2-29	OX Receptor	GPCR/G Protein; Neuroscience
	TCS-OX2-29 是高亲和力和选择性OX2R 拮抗剂，IC50值为 40 nM，pKI 值为 7.5。它对 OX2 的选择性比 OX1 高 250 倍以上。
T12877	Seltorexant hydrochloride JNJ-42847922 hydrochloride	Others	Others
	Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.
T39808	Firazorexton
	Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.
T24013	DORA 42 DORA42,DORA-42
	DORA 42 is a dual antagonist of the orexin receptor OX1R and OX2R.
T62050	Orexin receptor antagonist 4
	Orexin receptor antagonist 4 是有效的选择性食欲素 2 受体 (OX2R) 拮抗剂。Orexin receptor antagonist 4 抑制 OX2R 和 OX1R 的 IC50分别为 4.27 nM 和295 nM。
T39004	Vornorexant ORN-0829,TS-142
	Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC 50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.
T78636	Firazorexton hydrate TAK-994
	Firazorexton hydrate (TAK-994)为一种高效的食欲素2型受体(OX2R)激动剂，EC50值为19 nM。在发作性睡病小鼠模型中，该化合物能够有效减少觉醒碎片和猝倒样发作的发生。

化合物

Orexin 2 Receptor Agonist

Cat.No: T3177

Synonym: OX2R

Target: OX Receptor

Cat.No: T62855

Cat.No: T3722

Synonym: Urokinase inhibitor 1,MK 1064

Target: OX Receptor

Cat.No: T39229

Target: OX Receptor

Cat.No: T12877L

Synonym: JNJ-42847922

Target: OX Receptor

Cat.No: T5503

Target: OX Receptor

Cat.No: T4965

Target: OX Receptor

Seltorexant hydrochloride

Cat.No: T12877

Synonym: JNJ-42847922 hydrochloride

Target: Others

Cat.No: T39808

Cat.No: T24013

Synonym: DORA42,DORA-42

Orexin receptor antagonist 4

Cat.No: T62050

Cat.No: T39004

Synonym: ORN-0829,TS-142

Firazorexton hydrate

Cat.No: T78636

Synonym: TAK-994

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01302	CD200R Protein, Human, Recombinant (His) HCRTR2,OX2R,MOX2R,CD200R...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-01665	CD200R Protein, Mouse, Recombinant (His) Mox2r,OX2R,CD200 recepto...	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-01092	CD200R Protein, Mouse, Recombinant (His & hFc) OX2R,CD200 receptor 1,Mox2r	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-01261	CD200R Protein, Human, Recombinant (His & hFc) CD200R,MOX2R,CD200 receptor 1,OX<...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPK-01262	CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His) CD200 receptor 1,OX2R,MOX2R	Cynomolgus	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPK-00623	CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated CRTR2,MOX2R,OX2R,CD200 R...	Human	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPK-00622	CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi) OX2R,CD200R,MOX2R,CD200 ...	Human	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPK-00624	CD200R1/CRTR2 Protein, Human, Recombinant (hFc) MOX2R,CRTR2,CD200R,HCRTR2,CD200 R1,MOX...	Human	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His) Cell Surface Glycoprotein CD200 Receptor 1,OX2R...	Human	Human Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla...

重组蛋白

CD200R Protein, Human, Recombinant (His)

Cat.No: TMPY-01302

Species: Human

Expression System: HEK293

CD200R Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01665

Species: Mouse

Expression System: HEK293

CD200R Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01092

Species: Mouse

Expression System: HEK293

CD200R Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01261

Species: Human

Expression System: HEK293

CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01262

Species: Cynomolgus

Expression System: HEK293

CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00623

Species: Human

Expression System: HEK293

CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00622

Species: Human

Expression System: HEK293

CD200R1/CRTR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00624

Species: Human

Expression System: HEK293

CD200R1/CRTR2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00233

Species: Human

Expression System: Human Cells

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