Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IPSU 是可口服和脑渗透性的选择性OX2R 拮抗剂,pKi 值为7.85。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 347 | 现货 | ||
2 mg | ¥ 519 | 现货 | ||
5 mg | ¥ 892 | 现货 | ||
10 mg | ¥ 1,180 | 现货 | ||
25 mg | ¥ 2,430 | 现货 | ||
50 mg | ¥ 3,650 | 现货 | ||
100 mg | ¥ 5,180 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 981 | 现货 |
产品描述 | IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. |
靶点活性 | OX2:7.85 (pKi) , OX1:6.29 (pKi) |
体外活性 | BBAC or the selective OX2R antagonist IPSU bind rapidly and reach equilibrium very quickly in binding and/or functional assays[1]. |
体内活性 | IPSU?exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration.?IPSU increases sleep when dosed during the mouse active phase (lights off);?IPSU induces sleep primarily by increasing NREM sleep.?IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing.?The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day[2] |
分子量 | 405.49 |
分子式 | C23H27N5O2 |
CAS No. | 1373765-19-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (73.98 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4662 mL | 12.3308 mL | 24.6615 mL | 61.6538 mL |
5 mM | 0.4932 mL | 2.4662 mL | 4.9323 mL | 12.3308 mL | |
10 mM | 0.2466 mL | 1.2331 mL | 2.4662 mL | 6.1654 mL | |
20 mM | 0.1233 mL | 0.6165 mL | 1.2331 mL | 3.0827 mL | |
50 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL | 1.2331 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IPSU 1373765-19-5 GPCR/G Protein Neuroscience OX Receptor inhibit HCRT Receptor Hypocretin Receptor Orexin Receptor (OX Receptor) Inhibitor inhibitor