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搜索结果

Search Results for " opg "
Targets Recommended: NOD

5

抑制剂 & 化合物

1

天然产物

26

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T16159 Muramyl dipeptide

MDP

 NOD Immunology/Inflammation; NF-κB
Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T70061 CGP 71683 (free base)

CGP 71683 (free base) is a potent and highly selective non-peptide antagonist of the NPY Y(5) receptor in the study of obesity.
TF0085 POPG

POPG 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0085，CAS号为 268550-95-4。
T67069 DOPG sodium

DOPG sodium 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67069，CAS号为 67254-28-8。
T72008 E09241

E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling.

化合物

Muramyl dipeptide
Cat.No: T16159
Synonym: MDP
Target: NOD
CGP 71683 (free base)
Cat.No: T70061
Synonym:
Target:
POPG
Cat.No: TF0085
Synonym:
Target:
DOPG sodium
Cat.No: T67069
Synonym:
Target:
E09241
Cat.No: T72008
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T5720 Boldine

1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus

 RANKL/RANK NF-κB
Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱，从山苍子根中提取获得，具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成，并利用下调 OPG/RANKL/RANK 信号途径，改善骨破坏。它可用于研究类风湿性关节炎。

天然产物

Boldine
Cat.No: T5720
Synonym: 1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus
Target: RANKL/RANK
Species：
VACV (15)
Human (5)
Mouse (3)
VARV (3)
Expression System：
E. coli (12)
HEK293 Cells (8)
P. pastoris (Yeast) (4)
Baculovirus Insect Cells (2)
Tag：
N-6xHis (9)
N-10xHis, C-Myc (7)
C-6xHis (3)
C-hFc (2)
C-10xHis (1)
His (1)
N-10xHis (1)
N-6xHis-SUMO (1)
hFc (1)
Cat. No. Product Name Species Expression System
TMPJ-00253 OPG Protein, Mouse, Recombinant (His)

Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory fa...

 Mouse HEK293 Cells
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ...
TMPY-02726 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)

RANKL,OPGL,Trance,OPG,tumor necrosis facto...

 Mouse HEK293 Cells
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is AAC40113.1.
TMPJ-01466 Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)

OPG,Tumor Necrosis Factor Receptor Superfamily Memb...

 Human HEK293 Cells
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF...
TMPY-04509 Osteoprotegerin Protein, Mouse, Recombinant (hFc)

tumor necrosis factor receptor superfamily member 11b,Op...

 Mouse HEK293 Cells
Osteoprotegerin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.2 kDa and the accession number is O08712.
TMPY-01724 Osteoprotegerin Protein, Human, Recombinant (His)

OCIF,OPG,MGC29565,TR1,PDB5,tumor necrosis factor re...

 Human HEK293 Cells
Osteoprotegerin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is O00300.
TMPY-05262 Osteoprotegerin Protein, Human, Recombinant (hFc)

MGC29565,OPG,PDB5,tumor necrosis factor receptor su...

 Human Baculovirus Insect Cells
Osteoprotegerin Protein, Human, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 70.3 kDa and the accession number is O00300.
TMPH-03678 Vaccinia virus (strain Copenhagen) OPG125 Protein (His & Myc)

VACV E. coli
Vaccinia virus (strain Copenhagen) OPG125 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.2 kDa and the accession number is P68441.
TMPH-03667 Vaccinia virus (strain Copenhagen) OPG190 Protein (His)

VACV P. pastoris (Yeast)
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EEV) to allow virion entry into host cells. Participates also in wrapping intracellular mature virions (IMV) to form intracellular enveloped virions (IEV). Vaccinia virus (strain Copenhagen) OPG190 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is P21115.
TMPH-03655 Vaccinia virus (strain Copenhagen) OPG105 Protein (His & SUMO)

VACV E. coli
Binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell. Vaccinia virus (strain Copenhagen) OPG105 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.3 kDa and the accession number is P20508.
TMPH-03664 Vaccinia virus (strain Western Reserve) OPG161 Protein (His)

VACV P. pastoris (Yeast)
Coordinates the incorporation of A36 into wrapped enveloped virion (EV) membranes and, subsequently, the production of actin tails. Therefore plays an essential role in efficient cell-to-cell spread of viral particles. Vaccinia virus (strain Western Reserve) OPG161 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.2 kDa and the accession number is P68617.
TMPH-03677 Vaccinia virus (strain Copenhagen) OPG065 Protein (His & Myc)

VACV E. coli
Vaccinia virus (strain Copenhagen) OPG065 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.5 kDa and the accession number is P21081.
TMPH-03665 Vaccinia virus (strain Copenhagen) OPG185 Protein (His)

VACV E. coli
Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation. Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack. Vaccinia virus (strain Copenhagen) OPG185 Protein (His) is expressed in E. coli expression system with ...
TMPH-03660 Vaccinia virus (strain Lister) OPG190 Protein (His)

VACV E. coli
Regulation of plaque size and host range. Vaccinia virus (strain Lister) OPG190 Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.2 kDa and the accession number is P24083.
TMPH-03669 Vaccinia virus (strain Western Reserve) OPG190 Protein (His)

VACV P. pastoris (Yeast)
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EV) to allow virion entry into host cells. Participates also in wrapping mature virions (MV) to form enveloped virions (EV). Vaccinia virus (strain Western Reserve) OPG190 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is Q01227.
TMPH-03661 Vaccinia virus (strain Western Reserve) OPG154 Protein (His & Myc)

VACV E. coli
Structural protein involved in the envelopment of mature virion (MV) to form the wrapped virion (WV). The wrapping consists of the addition of Golgi membranes to the mature virion. Participates in mature virion (MV) movement within the infected cell. May play an indirect role in MV-cell fusion. Vaccinia virus (strain Western Reserve) OPG154 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.6 kDa and the accession numbe...
TMPH-03659 Vaccinia virus (strain Western Reserve) OPG094 Protein (His)

VACV P. pastoris (Yeast)
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation). Vaccinia virus (strain Western Reserve) OPG094 Protein (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 37.8 kDa and the accession number is P07611.
TMPH-03666 Vaccinia virus (strain Copenhagen) OPG190 Protein (His & Myc)

VACV E. coli
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EEV) to allow virion entry into host cells. Participates also in wrapping intracellular mature virions (IMV) to form intracellular enveloped virions (IEV). Vaccinia virus (strain Copenhagen) OPG190 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 36.5 kDa and the accession number is P21115.
TMPH-03657 Vaccinia virus (strain Western Reserve) OPG057 Protein (His & Myc)

VACV E. coli
Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell. Produces the wrapped form of virus that is required for cell-to-cell spread. Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities. Vaccinia virus (strain Western Reserve) OPG057 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight ...
TMPH-03663 Vaccinia virus (strain Copenhagen) OPG161 Protein (A33R, His)

VACV Baculovirus Insect Cells
Coordinates the incorporation of A36 into intracellular enveloped virion (IEV) membranes and, subsequently, the production of actin tails. Therefore plays an essential role in efficient cell-to-cell spread of viral particles. Vaccinia virus (strain Copenhagen) OPG161 Protein (A33R, His) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 18.3 kDa and the accession number is P68616.
TMPH-03668 Vaccinia virus (strain Western Reserve) OPG190 Protein (E. coli, His)

VACV E. coli
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EV) to allow virion entry into host cells. Participates also in wrapping mature virions (MV) to form enveloped virions (EV). Vaccinia virus (strain Western Reserve) OPG190 Protein (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.2 kDa and the accession number is Q01227.
TMPH-03686 Variola virus (isolate Human/India/Ind3/1967) OPG154 Protein (His)

VARV HEK293 Cells
Structural protein involved in the envelopment of mature virion (MV) to form the wrapped virion (WV). The wrapping consists of the addition of Golgi membranes to the mature virion. Participates in mature virion (MV) movement within the infected cell. May play an indirect role in MV-cell fusion. Variola virus (isolate Human/India/Ind3/1967) OPG154 Protein (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 16.5 kDa and the accession number is P33816.
TMPH-03662 Vaccinia virus (strain Copenhagen) OPG161 Protein (A33R, E. coli, His)

VACV E. coli
Coordinates the incorporation of A36 into intracellular enveloped virion (IEV) membranes and, subsequently, the production of actin tails. Therefore plays an essential role in efficient cell-to-cell spread of viral particles. Vaccinia virus (strain Copenhagen) OPG161 Protein (A33R, E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.8 kDa and the accession number is P68616.
TMPH-03688 Variola virus (isolate Human/India/Ind3/1967) OPG057 Protein (His & Myc)

VARV E. coli
Envelope protein associated with the inner side of the enveloped virion (EV) membrane. Variola virus (isolate Human/India/Ind3/1967) OPG057 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.4 kDa and the accession number is P33815.
TMPH-03687 Variola virus (isolate Human/India/Ind3/1967) OPG154 Protein (E. coli, His)

VARV E. coli
Structural protein involved in the envelopment of mature virion (MV) to form the wrapped virion (WV). The wrapping consists of the addition of Golgi membranes to the mature virion. Participates in mature virion (MV) movement within the infected cell. May play an indirect role in MV-cell fusion. Variola virus (isolate Human/India/Ind3/1967) OPG154 Protein (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.6 kDa and the accession number ...
TMPJ-00349 RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O...

 Human HEK293 Cells
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPH-02264 TNFSF11 Protein, Human, Recombinant (His)

Human HEK293 Cells
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl...

重组蛋白

OPG Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00253
Species: Mouse
Expression System: HEK293 Cells
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02726
Species: Mouse
Expression System: HEK293 Cells
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
Cat.No: TMPJ-01466
Species: Human
Expression System: HEK293 Cells
Osteoprotegerin Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-04509
Species: Mouse
Expression System: HEK293 Cells
Osteoprotegerin Protein, Human, Recombinant (His)
Cat.No: TMPY-01724
Species: Human
Expression System: HEK293 Cells
Osteoprotegerin Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05262
Species: Human
Expression System: Baculovirus Insect Cells
Vaccinia virus (strain Copenhagen) OPG125 Protein (His & Myc)
Cat.No: TMPH-03678
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Copenhagen) OPG190 Protein (His)
Cat.No: TMPH-03667
Species: VACV
Expression System: P. pastoris (Yeast)
Vaccinia virus (strain Copenhagen) OPG105 Protein (His & SUMO)
Cat.No: TMPH-03655
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Western Reserve) OPG161 Protein (His)
Cat.No: TMPH-03664
Species: VACV
Expression System: P. pastoris (Yeast)
Vaccinia virus (strain Copenhagen) OPG065 Protein (His & Myc)
Cat.No: TMPH-03677
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Copenhagen) OPG185 Protein (His)
Cat.No: TMPH-03665
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Lister) OPG190 Protein (His)
Cat.No: TMPH-03660
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Western Reserve) OPG190 Protein (His)
Cat.No: TMPH-03669
Species: VACV
Expression System: P. pastoris (Yeast)
Vaccinia virus (strain Western Reserve) OPG154 Protein (His & Myc)
Cat.No: TMPH-03661
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Western Reserve) OPG094 Protein (His)
Cat.No: TMPH-03659
Species: VACV
Expression System: P. pastoris (Yeast)
Vaccinia virus (strain Copenhagen) OPG190 Protein (His & Myc)
Cat.No: TMPH-03666
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Western Reserve) OPG057 Protein (His & Myc)
Cat.No: TMPH-03657
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Copenhagen) OPG161 Protein (A33R, His)
Cat.No: TMPH-03663
Species: VACV
Expression System: Baculovirus Insect Cells
Vaccinia virus (strain Western Reserve) OPG190 Protein (E. coli, His)
Cat.No: TMPH-03668
Species: VACV
Expression System: E. coli
Variola virus (isolate Human/India/Ind3/1967) OPG154 Protein (His)
Cat.No: TMPH-03686
Species: VARV
Expression System: HEK293 Cells
Vaccinia virus (strain Copenhagen) OPG161 Protein (A33R, E. coli, His)
Cat.No: TMPH-03662
Species: VACV
Expression System: E. coli
Variola virus (isolate Human/India/Ind3/1967) OPG057 Protein (His & Myc)
Cat.No: TMPH-03688
Species: VARV
Expression System: E. coli
Variola virus (isolate Human/India/Ind3/1967) OPG154 Protein (E. coli, His)
Cat.No: TMPH-03687
Species: VARV
Expression System: E. coli
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
Cat.No: TMPJ-00349
Species: Human
Expression System: HEK293 Cells
TNFSF11 Protein, Human, Recombinant (His)
Cat.No: TMPH-02264
Species: Human
Expression System: HEK293 Cells
TargetMol®
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