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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27794 |
λ-Cyhalothrin
lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon |
Sodium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
λ-Cyhalothrin (Icon) 是广谱的 II 型合成除虫菊酯杀虫剂,含有 α-氰基,用于防治多种害虫。它是一种钠通道神经毒素,靶向中枢神经系统中神经元膜。 | |||
T33346 |
Methylaminoalanine-nickel(II)
L-Bmma-nickel(II),L-Medap-nickel(II) |
Others | Others |
Methylaminoalanine-nickel(II) can be regarded as a naturally occurring neurotoxin. | |||
T80427 |
Jingzhaotoxin-II
|
Sodium Channel | Membrane transporter/Ion channel |
Jingzhaotoxin-II是由32个氨基酸组成的神经毒素,包括两个酸性残基和两个碱性残基。该毒素能够抑制电压门控钠通道(VGSC),并在心肌细胞上明显减缓TTX抗性(TTX-R) VGSC的快速失活,其IC50值为0.26μM。 | |||
TP2016 |
Huwentoxin-IV
Huwentoxin IV |
||
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin recepto |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00054 |
AaH II Protein, Androctonus australis, Recombinant (His & SUMO)
Toxin II,Neurotoxin II,AaHII<... |
Androctonus australis | E. coli |
AaH II Protein, Androctonus australis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.3 kDa and the accession number is P01484. | |||
TMPH-00056 |
Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)
ATX II,Delta-AITX-Avd1c,Toxin II,Delta-act... |
Anemonia sulcata | P. pastoris (Yeast) |
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured... |