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Search Results for " nr1 "

Targets Recommended: mTOR

10

抑制剂 & 化合物

1

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16741	Rheb inhibitor NR1	mTOR	PI3K/Akt/mTOR signaling
	Rheb inhibitor NR1 是一种 Rheb 抑制剂和选择性 mTORC1 抑制剂。Rheb inhibitor NR1 可抑制 T389pS6K1 的磷酸化,促进S473pAKT 的磷酸化。
T22542	1-Aminocyclobutanecarboxylic acid ACBC,1-氨基环丁烷羧酸	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	1-Aminocyclobutanecarboxylic acid (ACBC) 是一种NMDA 受体部分激动剂，作用于 NR1 甘氨酸位点。
T81075	SUCNR1-IN-2
	SUCNR1-IN-2 (Statement 35) 作为succinate/succinate受体 1 抑制剂，专用于神经退行性疾病（例如神经炎症）的研究领域。
T30554	bNR10S bNR 10S,bNR-10S
	bNR10S is a solvatochromic nile red probe with FRET quencher reveal lipid order heterogeneity in living and apoptotic cells.
T79207	SUCNR1-IN-1
	SUCNR1-IN-1（Compound 20）是针对SUCNR1的抑制剂，IC50值为88 nM（针对hSUCNR1）。该化合物可应用于类风湿关节炎、肝纤维化以及肥胖相关研究。
T36474	TunR1
	TunR1 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. TunR1 (5 μg/ml) is cytotoxic to MDA-MB-231 breast cancer cells and non-cancerous CHO cells. Unlike tunicamycin, TunR1 does not inhibit glycosylation in a protein N-glycosylation assay. 1.Price, N.P., Hartman, T.M., Li, J., et al.Modified...
T12251	NR1H4 activator 1	Others	Others
	NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).
T8450	TCN 213 TCN213	NMDAR	Neuroscience
	TCN 213 是一种可克服的(surmountable)、甘氨酸依赖的 GluN1/GluN2A NMDAR 选择性拮抗剂，当甘氨酸的含量为75、 750、7500 nM 时，IC50s 值分别为 0.55、3.5、40 μM。它可用于在药理学上监测 NMDAR 表达在发育中的皮层神经元中的转换。
T37671	CAY10608 CAY10608
	N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM). It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. CAY...
T37215	5α,6β-Dihydroxycholestanol
	5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 uM. It increases survival of spinal cord motoneurons, cortical neurons, a...

化合物

Rheb inhibitor NR1

Cat.No: T16741

Target: mTOR

1-Aminocyclobutanecarboxylic acid

Cat.No: T22542

Synonym: ACBC,1-氨基环丁烷羧酸

Target: NMDAR, iGluR

Cat.No: T81075

Cat.No: T30554

Synonym: bNR 10S,bNR-10S

Cat.No: T79207

Cat.No: T36474

NR1H4 activator 1

Cat.No: T12251

Target: Others

Cat.No: T8450

Synonym: TCN213

Target: NMDAR

Cat.No: T37671

Synonym: CAY10608

5α,6β-Dihydroxycholestanol

Cat.No: T37215

Cat. No.	Product Name	Target	Signaling Pathways
T2S1008	Oxysophoridine Sophoridine N-oxide,氧化槐定碱	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱，具有抗发炎，抗氧化应激和抗凋亡的作用。

天然产物

Cat.No: T2S1008

Synonym: Sophoridine N-oxide,氧化槐定碱

Target: Apoptosis, Antioxidant

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01250	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) AI314697,Il11ra1,interle...	Mouse	HEK293 Cells
	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is Q64385.
TMPY-06756	NR1H4 Protein, Mouse, Recombinant (His) nuclear receptor subfamily 1, group H, member 4,AI9...	Mouse	E. coli
	NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.
TMPH-01793	NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
TMPH-03256	CNR1 Protein, Rat, Recombinant (His) Skr6,Brain-type cannabinoid receptor,Cannabinoid receptor	Rat	E. coli
	CNR1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 58.9 kDa and the accession number is P20272.
TMPY-06768	NR1H4 Protein, Human, Recombinant (His) FXR,BAR,nuclear receptor subfamily 1, group H, memb...	Human	E. coli
	NR1H4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.83 kDa and the accession number is Q96RI1-1.
TMPH-01035	CNR1 Protein-VLP, Human, Recombinant (His) Cnr1,Skr6,CB1,CB-R,Cannabinoid re...	Human	HEK293 Cells
	CNR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 54.6 kDa and the accession number is P21554.
TMPY-01733	SIGNR1 Protein, Mouse, Recombinant (His) CD209b antigen,DC-SIGNR1,OtB7,SIGNR	Mouse	HEK293 Cells
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...

重组蛋白

IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01250

Species: Mouse

Expression System: HEK293 Cells

NR1H4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06756

Species: Mouse

Expression System: E. coli

NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01793

Species: Human

Expression System: E. coli

CNR1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03256

Species: Rat

Expression System: E. coli

NR1H4 Protein, Human, Recombinant (His)

Cat.No: TMPY-06768

Species: Human

Expression System: E. coli

CNR1 Protein-VLP, Human, Recombinant (His)

Cat.No: TMPH-01035

Species: Human

Expression System: HEK293 Cells

SIGNR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01733

Species: Mouse

Expression System: HEK293 Cells

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